Combined Cilioretinal Artery and Central Retinal Vein Occlusion Treated with a Single Injection of Ranibizumab

Introduction

Central retinal vein occlusion (CRVO), although a common vision-impairing condition, may rarely be associated with cilioretinal artery occlusion (CAO) [1]. We hereby describe the clinical findings and course of two patients presented with combined CAO and CRVO and treated with a single intravitreal injection of ranibizumab. We also perform a review of the literature. This is the first reported case in the literature of combined CAO and CRVO treated with intravitreal ranibizumab.

References

• 1 Theoulakis P E, Livieratou A, Petropoulos I K et al. Cilioretinal artery occlusion combined with central retinal vein occlusion – a report of two cases and review of the literature.  Klin Monatsbl Augenheilkd. 2010;  227 302-305
• 2 Oosterhuis J A. Fluorescein fundus angiography in retinal venous occlusion. In: Henkes H E, (ed). Perspectives in Ophthalmology.. Amsterdam: Excerpta Medica Foundation; 1968: 29-47
• 3 Brown G C, Shields J A. Cilioretinal arteries and retinal arterial occlusion.  Arch Ophthalmol. 1979;  97 84-92
• 4 Brown D M, Campochiaro P A, Singh R P et al. Ranibizumab for macular edema following central retinal vein occlusion: six-month primary end point results of a phase III study.  Ophthalmology. 2010;  117 1124-1133
• 5 McLeod D. Central retinal vein occlusion with cilioretinal infarction from branch flow exclusion and choroidal arterial steal.  Retina. 2009;  29 1381-1395
• 6 Hayreh S S, Fraterrigo L, Jonas J. Central retinal vein occlusion associated with cilioretinal artery occlusion.  Retina. 2008;  28 581-594
• 7 Aiello L P, Avery R L, Arrigg P G et al. Vascular endothelial growth factor in ocular fluid of patients with diabetic retinopathy and other retinal disorders.  N Engl J Med. 1994;  331 1480-1487
• 8 Pe’er J, Folberg R, Itin A et al. Vascular endothelial growth factor upregulation in human central retinal vein occlusion.  Ophthalmology. 1998;  105 412-416