Planta Med 2011; 77(16): 1829-1834
DOI: 10.1055/s-0030-1271196
Natural Product Chemistry
Original Papers
© Georg Thieme Verlag KG Stuttgart · New York

Three New Cycloartane Triterpenoids from Astragalus bicuspis

Saleem Jan1 , 3 , Ahmed Abbaskhan1 , Syed Ghulam Musharraf1 , Samina A. Sattar1 ,  Samreen1 , Saud I. Resayes2 , Zeid A. Al-Othman2 , Abdullah M. Al-Majid2 ,  Atta-ur-Rahman1 , M. Iqbal Choudhary1 , 2
  • 1H. E. J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, Pakistan
  • 2Department of Chemistry, King Saud University, Riyadh, Saudi Arabia
  • 3Department of Chemistry, University of Science and Technology, Bannu, Pakistan
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Publikationsverlauf

received March 10, 2011 revised May 10, 2011

accepted May 13, 2011

Publikationsdatum:
15. Juli 2011 (online)

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Abstract

Three new cycloartane triterpenoids have been isolated from Astragalus bicuspis Fisch. Their structures were elucidated as 23(R),24(S),25(R),26(S)-16β/23,23/26,24/25-triepoxy-26-hydroxy-9,19-cyclolanosta-3,6-dione (1), 6α,23,24,25-tetraol-16β-acetoxy-23(R),24(R)-9,19-cyclanosta-3-one (2), and 6α,23,24,25-tetraol-16β-acetoxy-23(R),24(R)-9,19-cyclolanosta-3β-O-xyloside (3), based on their spectroscopic analysis. All cycloartane tritepenoids exhibited weak cytotoxicities against 3T3 fibroblast cells as compared to the standard drug cycloheximide. Compounds 3 and 4 were also tested for their antileishmanial potential, and a weak activity was observed against promastigotes of Leishmania major.

References

Prof. M. Iqbal Choudhary

H. E. J. Research Institute of Chemistry
International Center for Chemical and Biological Sciences
University of Karachi

Karachi 75270

Pakistan

Telefon: +92 21 48 24 92 45

Fax: +92 21 48 19 01 89

eMail: hej@cyber.net.pk