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DOI: 10.1055/s-0030-1271196
© Georg Thieme Verlag KG Stuttgart · New York
Three New Cycloartane Triterpenoids from Astragalus bicuspis
Publication History
received March 10, 2011
revised May 10, 2011
accepted May 13, 2011
Publication Date:
15 July 2011 (online)
Abstract
Three new cycloartane triterpenoids have been isolated from Astragalus bicuspis Fisch. Their structures were elucidated as 23(R),24(S),25(R),26(S)-16β/23,23/26,24/25-triepoxy-26-hydroxy-9,19-cyclolanosta-3,6-dione (1), 6α,23,24,25-tetraol-16β-acetoxy-23(R),24(R)-9,19-cyclanosta-3-one (2), and 6α,23,24,25-tetraol-16β-acetoxy-23(R),24(R)-9,19-cyclolanosta-3β-O-xyloside (3), based on their spectroscopic analysis. All cycloartane tritepenoids exhibited weak cytotoxicities against 3T3 fibroblast cells as compared to the standard drug cycloheximide. Compounds 3 and 4 were also tested for their antileishmanial potential, and a weak activity was observed against promastigotes of Leishmania major.
Key words
Astragalus bicuspis - Leguminosae - cycloartane triterpenoids - antileishmanial activity - cytotoxicity - 3T3 fibroblast cell line
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Prof. M. Iqbal Choudhary
H. E. J. Research Institute of Chemistry
International Center for Chemical and Biological Sciences
University of Karachi
Karachi 75270
Pakistan
Phone: +92 21 48 24 92 45
Fax: +92 21 48 19 01 89
Email: hej@cyber.net.pk