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Thorac Cardiovasc Surg 2012; 60(06): 421-424
DOI: 10.1055/s-0030-1271043
Case Reports
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Sentinel Node Microscopic Metastasis Detected after Segmentectomy for Lung Cancer Followed by Completion Lobectomy: Two Case Reports

T. Fukutomi
1   Department of Surgery, School of Medicine, Keio University, Tokyo, Japan
,
M. Kohno
1   Department of Surgery, School of Medicine, Keio University, Tokyo, Japan
,
Y. Izumi
1   Department of Surgery, School of Medicine, Keio University, Tokyo, Japan
,
Y. Hayashi
2   Department of Pathology, School of Medicine, Keio University, Tokyo, Japan
,
T. Nakahara
3   Department of Radiology, School of Medicine, Keio University, Tokyo, Japan
,
H. Nomori
1   Department of Surgery, School of Medicine, Keio University, Tokyo, Japan
› Author Affiliations
Further Information

Publication History

03 February 2011
25 February 2011

14 March 2011

Publication Date:
12 May 2011 (online)

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Abstract

We performed sentinel node identification using radioisotopic and/or dye techniques to determine the final indication after segmentectomy in cases with non-small cell lung cancer. Sentinel nodes were examined using intraoperative frozen sections stained with hematoxylin and eosin. We present 2 cases with completion lobectomy performed 7 and 11 days after segmentectomy because immunohistochemical staining of the sentinel nodes showed the presence of microscopic metastases that were not detected by the examination of intraoperative frozen sections.

Keywords

lung cancer treatment (surgery, medical) - lung cancer - diagnosis (includes staging, imaging, fiducials) - metastases - non-small cell lung cancer - sentinel node - segmentectomy - micrometastasis
 

  • References

  • 1 Okada M, Koike T, Higashiyama M, Yamato Y, Kodama K, Tsubota N. Radical sublobar resection for small-sized non-small cell lung cancer: a multicenter study. J Thorac Cardiovasc Surg 2006; 132 (4) 769-775
    CrossrefPubMedGoogle Scholar
  • 2 Nomori H, Ikeda K, Mori T , et al. Sentinel node navigation segmentectomy for clinical stage IA non-small cell lung cancer. J Thorac Cardiovasc Surg 2007; 133 (3) 780-785
    CrossrefPubMedGoogle Scholar
  • 3 Nomori H, Watanabe K, Ohtsuka T, Naruke T, Suemasu K. In vivo identification of sentinel lymph nodes for clinical stage I non-small cell lung cancer for abbreviation of mediastinal lymph node dissection. Lung Cancer 2004; 46 (1) 49-55
    CrossrefPubMedGoogle Scholar
  • 4 Yamashita S, Tokuishi K, Anami K , et al. Video-assisted thoracoscopic indocyanine green fluorescence imaging system shows sentinel lymph nodes in non-small-cell lung cancer. J Thorac Cardiovasc Surg 2011; 141 (1) 141-144
    CrossrefPubMedGoogle Scholar
  • 5 Tezel C, Ersev AA, Kiral H , et al. The impact of immunohistochemical detection of positive lymph nodes in early stage lung cancer. Thorac Cardiovasc Surg 2006; 54 (2) 124-128
    Article in Thieme ConnectPubMedGoogle Scholar
  • 6 Osaki T, Oyama T, Gu CD , et al. Prognostic impact of micrometastatic tumor cells in the lymph nodes and bone marrow of patients with completely resected stage I non-small-cell lung cancer. J Clin Oncol 2002; 20: 2930-2936
    CrossrefPubMedGoogle Scholar
  • 7 The Japan Lung Cancer Society.. General Rule for Clinical and Pathological Record of Lung Cancer. 7th ed. Tokyo:: Kanehara; 2010: 91-92
    Google Scholar
  • 8 Nicholson AG, Graham AN, Pezzella F, Angeta G, Goldstraw P, Pastorino U. Does the use of immunohistochemistry to identify micrometastases provide useful information in the staging of node negative non-small cell lung cancer?. Lung Cancer 1997; 18: 231-240
    PubMedGoogle Scholar
  • 9 Marchevsky AM, Qiao JH, Krajisnik S, Mirocha JM, McKenna RJ. The prognostic significance of intranodal isolated tumor cells and micrometastases in patients with non-small cell carcinoma of the lung. J Thorac Cardiovasc Surg 2003; 126 (2) 551-557
    CrossrefPubMedGoogle Scholar