ABSTRACT
Evidence is emerging that tissue-factor–bearing microparticles and other microparticles
arise from regions of the parent cell's plasma membrane that are rich in lipid rafts.
In this brief review, we summarize the evidence for the raft origins of microparticles
and the implications of these origins for the biological and medical consequences
of microparticle production and for therapeutic strategies to diminish their production
and potential to do harm.
KEYWORDS
Tissue factor - lipid rafts - microparticles - thrombosis - cancer
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José A LópezM.D.
Research Division, Puget Sound Blood Center
921 Terry Avenue, Seattle, WA 98104
Email: josel@psbcresearch.org
