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Synfacts 2011(9): 0975-0975
DOI: 10.1055/s-0030-1261008
DOI: 10.1055/s-0030-1261008
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag
Stuttgart ˙ New York
Diastereoselective Rhodium-Catalyzed Switchable Three-Component Couplings
J. Ji, X. Zhang, Y. Zhu, Y. Qian, J. Zhou, L. Yang, W. Hu*
East China Normal University, Shanghai, P. R. of China
Weitere Informationen
Publikationsverlauf
Publikationsdatum:
19. August 2011 (online)
Significance
The authors report a diastereoselective rhodium-catalyzed three-component reaction using aryldiazoacetates, benzyl alcohols, and β,γ-unsaturated α-keto esters. The diastereoselectivity observed is switchable and predicated on the co-catalyst used (InBr3 vs. AgBF4). The authors claim the origin of the diastereoselectivity switch to lie in ‘chelation and non-chelation modes’ of control.