Synfacts 2011(9): 0934-0934  
DOI: 10.1055/s-0030-1260988
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of (-)-Conophylline

Contributor(s): Steven V. Ley, James R. Frost
Y. Han-ya, H. Tokuyama, T. Fukuyama*
The University of Tokyo and Tohoku University, Sendai, Japan
Further Information

Publication History

Publication Date:
19 August 2011 (online)

Significance

(-)-Conophylline was isolated from Tabernaemontana divaricata in 1992 and shows promising anticancer activity. This compound may become a lead for novel cancer chemotherapy drugs and in the treatment of diabetes mellitus type 1 through regeneration therapy. This work re-presents the first total synthesis of this compound.