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Synfacts 2011(9): 0994-0994
DOI: 10.1055/s-0030-1260907
DOI: 10.1055/s-0030-1260907
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag
Stuttgart ˙ New York
Copper-Catalyzed Asymmetric Hydrosilylation
X.-C. Zhang, F.-F. Wu, S. Li, J.-N. Zhou, J. Wu*, N. Li, W. Fang*, K. H. Lam, A. S. C. Chan*
Zhejiang University, Hangzhou, Hangzhou Normal University, The Hong Kong Polytechnic University and Hong Kong Baptist University, P. R. of China
Further Information
Publication History
Publication Date:
19 August 2011 (online)
Significance
The authors developed a highly practical and effective catalyst system for the asymmetric hydrosilylation of ketones. Employing copper(II)-dipyridylphosphine catalyst and PMHS (polymethylhydrosiloxane), which is an inexpensive, non-toxic, and air-stable hydride source, gave the desired products in good yield and enantioselectivity under mild conditions.