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Synfacts 2011(9): 0984-0984
DOI: 10.1055/s-0030-1260906
DOI: 10.1055/s-0030-1260906
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag
Stuttgart ˙ New York
Lithium Binaphtholate-Catalyzed Asymmetric Alkynylation of Ketones
K. Tanaka, K. Kukita, T. Ichibakase, S. Kotani, M. Nakajima*
Kumamoto University, Japan
Further Information
Publication History
Publication Date:
19 August 2011 (online)
Significance
The authors describe an asymmetric lithium binaphtholate catalyzed alkynylation of ketones. The simplicity of this method and the ready availability of the reagents and catalyst make this procedure particularly attractive.