Synfacts 2011(9): 1001-1001  
DOI: 10.1055/s-0030-1260876
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

Sequential Asymmetric Conjugate Addition and Oxidative Dearomatization

Contributor(s): Paul Knochel, Thomas Kunz
A. Rudolph, P. H. Bos, A. Meetsma, A. J. Minnaard, B. L. Feringa*
University of Groningen, The Netherlands
Further Information

Publication History

Publication Date:
19 August 2011 (online)

Significance

In this work, a sequential asymmetric conjugate addition and oxidative cyclization ­reaction is reported. In a single transformation, this process allows two carbon-carbon bond formations and leads to a spirocyclic framework with three adjacent stereocenters. Substituents on the substrate or the Grignard reagent are easily varied and allow the introduction of functionalities for further modifications of the scaffold.