Download PDF
Synfacts 2011(7): 0740-0740  
DOI: 10.1055/s-0030-1260639
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Iridium-Catalyzed anti-Diastereo- and Enantioselective Carbonyl Allylation

Contributor(s): Mark Lautens, Patrick T. Franke
X. Gao, Y. J. Zhang, M. J. Krische*
University of Texas at Austin, USA
Further Information

Publication History

Publication Date:
17 June 2011 (online)

    Permissions and Reprints

Significance

The authors report a protocol for anti-diastereo- and enantioselective carbonyl (α-trifluoromethyl)allylation. The allylated products were generally obtained in high yields with excellent levels of diastereo- and enantioselectivity. The ability to employ alcohols as starting material and catalytic organometallic reagents is noteworthy.