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Synfacts 2011(7): 0794-0794
DOI: 10.1055/s-0030-1260593
DOI: 10.1055/s-0030-1260593
Polymer-Supported Synthesis
© Georg Thieme Verlag
Stuttgart ˙ New York
Flow Oxidation Reactions Using Polystyrene-Supported Reagents
H. Lange, M. J. Capener, A. X. Jones, C. J. Smith, N. Nikbin, I. R. Baxendale, S. V. Ley*
University of Cambridge, UK
Further Information
Publication History
Publication Date:
17 June 2011 (online)
Significance
Stoichiometric and catalytic flow oxidation systems using polymer monolith-supported N-(tert-butyl)phenylsulfinimidoyl chloride M1 were developed. The flow oxidation of alcohols through the column containing a polystyrene-based monolith M1 afforded the corresponding carbonyl compounds during which M1 was reduced to N-(tert-butyl)phenylsulfenamide monolith M3. Monolith M1 was regenerated from M3 by passage of a solution of t-BuNCl2 or NCS through the column.