Synfacts 2011(7): 0769-0769  
DOI: 10.1055/s-0030-1260497
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

Diastereoselective Preparation of Cyclopropanols

Contributor(s): Paul Knochel, Thomas Kunz
K. Cheng, P. J. Carroll, P. J. Walsh*
University of Pennsylvania, Philadelphia, USA
Further Information

Publication History

Publication Date:
17 June 2011 (online)

Significance

In this work, a diastereoselective synthesis of trans-2-substituted cyclopropanols is described. The readily available dizinc reagent CH2(ZnI)2 reacts with various α-chloro aldehydes to give the corresponding trans-cyclopropanols in good to excellent yields and diastereomeric ratios.