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Synfacts 2011(7): 0777-0777  
DOI: 10.1055/s-0030-1260496
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

Asymmetric Addition of Arylboronic Acids to Isatins

Contributor(s): Paul Knochel, Thomas Kunz
Z. Liu, P. Gu, M. Shi*, P. McDowell, G. Li*
Shanghai Institute of Organic Chemistry, P. R. of China and Texas Tech University, Lubbock, USA
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Publication History

Publication Date:
17 June 2011 (online)

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Significance

Herein, a new catalytic system for the enantioselective arylation of isatins with arylboronic acids is reported. A chiral ­cationic C 2-symmetrical N-heterocyclic carbene Pd²+ diaqua complex is used as catalyst. The mild and convenient reaction conditions give the corresponding products in high yields and generally high enan­tioselectivities.