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Synfacts 2011(6): 0656-0656
DOI: 10.1055/s-0030-1259902
DOI: 10.1055/s-0030-1259902
Metal-Mediated Synthesis
© Georg Thieme Verlag
Stuttgart ˙ New York
Three-Component Cascade Reaction towards Substituted Tetrazoles
L. El Kaim*, L. Grimaud*, P. Patil
Ecole National Supérieure de Techniques Avancées, Paris, France
Further Information
Publication History
Publication Date:
19 May 2011 (online)
Significance
The authors report a three-component cascade for the preparation of substituted tetrazole heterocycles. The one-pot reaction sequence begins with the formation of dihalogeno isocyanides, which react with an azide nucleophile. After electrocyclization, the generated bromotetrazole undergoes a Suzuki coupling to afford a range of aryl tetrazoles in good yields.