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Synfacts 2011(6): 0655-0655  
DOI: 10.1055/s-0030-1259900
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of Polysubstituted Indoles via Three-Component Reaction

Contributor(s): Paul Knochel, Andreas J. Wagner
Z. Chen, D. Zheng, J. Wu*
Fudan University, Shanghai and Shanghai Institute of Organic Chemistry, P. R. of China
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Publication History

Publication Date:
19 May 2011 (online)

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Significance

A copper-catalyzed three-component reaction of 2-ethynylanilines, tosyl azide, and nitroolefins is reported. It proceeds under mild conditions and generates functionalized indoles in high yields.