Synthesis of an hNK-1 Receptor Antagonist

K. R. Campos; A. Klapars; Y. Kohmura; D. Polard; H. Ishibashi; S. Kato; A. Takezawa; J. H. Waldman; D. J. Wallace; C.-y. Chen; N. Yasuda

doi:10.1055/s-0030-1259893

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Synfacts 2011(6): 0578-0578
DOI: 10.1055/s-0030-1259893

Synthesis of Natural Products and Potential Drugs

Synthesis of an hNK-1 Receptor Antagonist

Contributor(s): Philip Kocienski
K. R. Campos*, A. Klapars, Y. Kohmura, D. Polard, H. Ishibashi, S. Kato, A. Takezawa, J. H. Waldman, D. J. Wallace, C.-y. Chen, N. Yasuda
Merck Research Laboratories, Rahway, USA

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Publication History

Publication Date:
19 May 2011 (online)

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Significance

An enantioselective synthesis of this hNK-1 antagonist features (1) a biocatalytic reduction of an enone to give alcohol A and (2) a palladium-catalyzed allylic etherification to construct the hindered ether linkage (D → F).