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Synfacts 2011(5): 0527-0527  
DOI: 10.1055/s-0030-1259872
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Palladium-Catalyzed Asymmetric [2,3] Rearrangements of Amine N-Oxides

Contributor(s): Hisashi Yamamoto, Jiajing Tan
H. Bao, X. Qi, U. K. Tambar*
The University of Texas Southwestern Medical Center at Dallas, USA
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Publication History

Publication Date:
15 April 2011 (online)

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Significance

The authors reported a highly efficient protocol of palladium-catalyzed enantioselective [2,3]-Meisenheimer-type rearrangement of allylic amine N-oxides. The corresponding chiral hydroxylamines were obtained with good yields and enantioselectivities.