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Synfacts 2011(5): 0561-0561  
DOI: 10.1055/s-0030-1259856
Organo- and Biocatalysis
© Georg Thieme Verlag Stuttgart ˙ New York

Michael Addition of Aldehydes to Vinyl Sulfones

Contributor(s): Benjamin List, Anna Lee
J. Xiao, Y.-P. Lu, Y.-L. Liu, P.-S. Wong, T.-P. Loh*
Nanyang Technological University, Singapore and Dalian Institute of Chemical Physics, P. R. of China
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Publication History

Publication Date:
15 April 2011 (online)

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Significance

Loh and co-workers report a catalytic asymmetric Michael addition of aldehydes to vinyl sulfones using newly designed catalyst 2, synthesized on the basis of natural product structures. The authors demonstrated that catalyst 2 is efficient in the Michael reaction of aldehydes to vinyl sulfones. This class of the Michael reaction typically requires high catalyst loading and low ­reaction temperature. The new catalyst system provides milder reaction conditions.