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Synfacts 2011(5): 0518-0518  
DOI: 10.1055/s-0030-1259824
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Palladium-Catalyzed Fluorination of Enynes

Contributor(s): Mark Lautens, Stephen G. Newman
H. Peng, G. Liu*
Shanghai Institute of Organic Chemistry, P. R. of China
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Publikationsdatum:
15. April 2011 (online)

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Significance

The construction of carbon-fluorine bonds is an important yet difficult task in the synthesis of pharmaceuticals. Based on previous ­results on aminofluorination of styrenes (J. Am. Chem. Soc. 2010, 132, 2856), the authors present a palladium-catalyzed tandem fluorination and cyclization of enynes to give vinyl fluorides.