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Synfacts 2011(5): 0462-0462
DOI: 10.1055/s-0030-1259788
DOI: 10.1055/s-0030-1259788
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag
Stuttgart ˙ New YorkSynthesis of (±)-Phantasmidine
Q. Zhou, B. B. Snider*
Brandeis University, Waltham, USA
Weitere Informationen
Publikationsverlauf
Publikationsdatum:
15. April 2011 (online)
Significance
Phantasmidine, a congener of epibatidine, was isolated from the epidermis of the Ecuadorian poison frog Epipedobates anthonyi in 1992 and was found to interact with β4-containing nicotinic receptors. A total synthesis of phantasmidine was targeted to enable a more detailed pharmacological analysis and structural determination.