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Synfacts 2011(1): 0116-0116  
DOI: 10.1055/s-0030-1259138
Polymer-Supported Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

PANI-AgNO3-PTSA Salt Catalyzed Mannich Reaction

Contributor(s): Yasuhiro Uozumi, Tsubasa Muto
S. Palaniappan*, B. Rajender
Indian Institute of Chemical Technology, Hyderabad, India
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Publication History

Publication Date:
21 December 2010 (online)

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Significance

The polyaniline-silver nitrate-p-toluenesulfonic acid (PANI-AgNO3-PTSA) salt catalyzed the Mannich reaction of cyclohexanone (1), benzaldehydes 2, and anilines 3 in water to give the corresponding β-amino ketones 4 in up to 96% yield with up to 100% anti selectivity (6 examples).