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Synfacts 2010(11): 1316-1316
DOI: 10.1055/s-0030-1258825
DOI: 10.1055/s-0030-1258825
Polymer-Supported Synthesis
© Georg Thieme Verlag
Stuttgart ˙ New York
Hydrogenation of Quinolines Using Pd0 Nanoparticles on Hydroxyapatite
N. Hashimoto, Y. Takahashi, T. Hara, S. Shimazu, T. Mitsudome, T. Mizugaki, K. Jitsukawa, K. Kaneda*
Osaka University, Toyonaka and Chiba University, Japan
Further Information
Publication History
Publication Date:
21 October 2010 (online)
Significance
The formation of Pd0 nanoparticles (Æ = 1-1.5 nm) on hydroxyapatite (HAP) and their application to regioselective hydrogenation is described. Treatment of HAP-bound PdCl2 with H2 for 30 min led to the HAP-supported Pd0 nanoparticles (Pd0HAP). Hydrogenation of quinolines using Pd0HAP gave the corresponding 1,2,3,4-tetrahydroquinolines.