Synfacts 2010(11): 1267-1267  
DOI: 10.1055/s-0030-1258806
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Ruthenium-Catalyzed Hydrogenative Desymmetrization of Bicyclic Amides

Contributor(s): Hisashi Yamamoto, Kimberly Griffin
M. Ito, C. Kobayashi, A. Himizu, T. Ikariya*
Tokyo Institute of Technology, Japan
Further Information

Publication History

Publication Date:
21 October 2010 (online)

Significance

The previously reported Cp*Ru(PN) ligand (Angew. Chem. Int. Ed. 2009, 48, 1324) is applied here to the asymmetric hydrogenation of monocyclic and bicyclic imides. This is a nice example of desymmetrization to generate new alcohols and imides.