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Synfacts 2010(11): 1264-1264  
DOI: 10.1055/s-0030-1258804
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Vanadium-Catalyzed Asymmetric Synthesis of Cyanohydrins

Contributor(s): Hisashi Yamamoto, Zhi Li
Y. Sakai, J. Mitote, K. Matsumoto, T. Katsuki*
Kyushu University, Fukuoka, Japan
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Publication History

Publication Date:
21 October 2010 (online)

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Significance

Cyanohydrins are highly important synthetic building blocks. This paper described that a chiral vanadium(salalen) complex was able to catalyze the asymmetric cyanation of aldehydes with acetone cyanohydrin. With as low as 0.2 mol% catalyst loading up to 95% ee of various cyanohydrins was obtained.