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Synfacts 2010(11): 1286-1286  
DOI: 10.1055/s-0030-1258724
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

Palladium-Catalyzed Oxidative Hydro-arylation of 1,3-Dienes with Boronic Esters

Contributor(s): Paul Knochel, Andreas J. Wagner
L. Liao, M. S. Sigman*
University of Utah, Salt Lake City, USA
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Publication History

Publication Date:
21 October 2010 (online)

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Significance

A palladium-catalyzed reductive cross-coupling of 1,3-dienes with boronic esters is reported. In this reaction, the palladium catalyst is reduced by isopropanol and then hydrometalates the 1,3-diene. The resulting π-allylpalladium species are readily arylated by a variety of aryl­boronic esters.