Subscribe to RSS
Please copy the URL and add it into your RSS Feed Reader.
https://www.thieme-connect.de/rss/thieme/en/10.1055-s-00000131.xml
Synfacts 2010(11): 1285-1285
DOI: 10.1055/s-0030-1258706
DOI: 10.1055/s-0030-1258706
Metal-Mediated Synthesis
© Georg Thieme Verlag
Stuttgart ˙ New York
A Novel General Phosphine Ligand for Suzuki-Miyaura Cross-Coupling
Contributor(s):Paul Knochel, Tobias ThalerW. Tang*, A. G. Capacci, X. Wei, W. Li, A. White, N. D. Patel, J. Savoie, J. J. Gao, S. Rodriguez, B. Qu, N. Haddad, B. Z. Lu, D. Krishnamurthy, N. K. Yee, C. H. Senanayake
Boehringer Ingelheim Pharmaceuticals Inc., Ridgefield, USA
A General and Special Catalyst for Suzuki-Miyaura Coupling Processes
Angew. Chem. Int. Ed. 2010, 49: 5879-5883
Boehringer Ingelheim Pharmaceuticals Inc., Ridgefield, USA
A General and Special Catalyst for Suzuki-Miyaura Coupling Processes
Angew. Chem. Int. Ed. 2010, 49: 5879-5883
Further Information
Publication History
Publication Date:
21 October 2010 (online)
Key words
phosphine ligands - Suzuki-Miyaura cross-coupling -
Significance
A new class of biaryl monophosphorous ligands with outstanding properties was developed. The ligand BI-DIME is highly air-stable and readily accessible in kilogram scale.
Comment
BI-DIME was tested as ligand in the palladium-catalyzed Suzuki-Miyaura reaction allowing for the first time the high-yielding cross-coupling of 2,4,6-triisopropylboronic acid with ortho-substituted aryl bromides.