Synfacts 2010(11): 1284-1284  
DOI: 10.1055/s-0030-1258705
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

O-Arylhydroxylamines and Benzofurans via O-Arylation of Ethyl Acetohydroximate

Contributor(s): Paul Knochel, Tobias Thaler
T. J. Maimone, S. L. Buchwald*
Massachusetts Institute of Technology, Cambridge, USA
Further Information

Publication History

Publication Date:
21 October 2010 (online)

Significance

The bulky ligands t-BuBrettPhos and t-BuXPhos were efficiently used in the palladium-catalyzed O-arylation of ethyl acetohydroximate. The resulting O-arylated products can be converted into the respective arylhydroxylamines or benzofurans.