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Synfacts 2010(10): 1146-1146  
DOI: 10.1055/s-0030-1258686
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Cobalt-Catalyzed HKR of Alkoxy- and Azido Epoxides

Contributor(s): Hisashi Yamamoto, Kimberly Griffin
R. S. Reddy, P. V. Chouthaiwale, G. Suryavanshi, V. B. Chavan, A. Sudalai*
National Chemical Laboratory, Pune, India
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Publikationsdatum:
22. September 2010 (online)

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Significance

Though Jacobsen’s hydrolytic kinetic resolution is well studied, the authors herein report the use of functionalized epoxides with two stereocenters for this reaction. The authors used two of their products as beginning substrates to biologically active molecules (S,S)-reboxetine and (+)-epi-cytoxazone.