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Synfacts 2010(10): 1164-1164  
DOI: 10.1055/s-0030-1258682
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Lewis Acid/Lewis Base Assisted Asymmetric Grignard Reaction

Contributor(s): Hisashi Yamamoto, Patrick Brady
X.-Y. Fan, Y.-X. Yang, F.-F. Zhuo, S.-L. Yu, X. Li, Q.-P. Guo, Z.-X. Du, C.-S. Da*
Lanzhou University, P. R. of China
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Publication History

Publication Date:
22 September 2010 (online)

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Significance

Judicious choice of additives allows for the addition of aryl Grignards to aldehydes with excellent yields and enantioselectivities. Importantly, the reaction takes place at room temperature in only three hours. Both aromatic and aliphatic aldehydes are well tolerated.