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Synfacts 2010(10): 1200-1200  
DOI: 10.1055/s-0030-1258666
Polymer-Supported Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of Quinazolines with Supported Copper Oxide Nanoparticles

Contributor(s): Yasuhiro Uozumi, Takao Osako
J. Zhang, C. Yu, S. Wang, C. Wan, Z. Wang*
University of Science and Technology of China, Hefei, P. R. of China
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Publication History

Publication Date:
22 September 2010 (online)

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Significance

Copper oxide nanoparticles supported on kaolin (SCONP) catalyzed the reaction of 2-acylanilines with benzylic amines in the presence of TBHP to give the corresponding quinazolines in up to 94% yield (28 examples). In the reaction of 2-aminobenzophenone with benzylamine, the catalyst was recovered by centrifugation and reused three times (1st reuse: 87% yield, 2nd reuse: 80% yield, 3rd reuse: 67% yield).