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Synfacts 2010(10): 1207-1207  
DOI: 10.1055/s-0030-1258665
Polymer-Supported Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

Pd/C-Catalyzed Oxidation of 1,2-Diarylalkynes with DMSO and O2

Contributor(s): Yasuhiro Uozumi, Yoichi M. A. Yamada, Toshihiro Watanabe
S. Mori, M. Takubo, T. Yanase, T. Maegawa, Y. Monguchi, H. Sajiki*
Gifu Pharmaceutical University and Osaka University, Japan
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Publication History

Publication Date:
22 September 2010 (online)

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Significance

Pd/C-catalyzed oxidation of 1,2-­diarylalkynes with dimethyl sulfoxide and O2 as dual oxidants gave the corresponding benzil derivatives 2a-k in 41-98% yield. The oxidation of 1a hardly proceeded in toluene and N,N-dimethyl­acetamide. The oxidation of 1a under an argon ­atmosphere was strongly suppressed even in DMSO (1a/2a = 71:29, ¹H NMR analysis).