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Synfacts 2010(10): 1138-1138  
DOI: 10.1055/s-0030-1258627
Synthesis of Materials and Unnatural Products
© Georg Thieme Verlag Stuttgart ˙ New York

Catalytic β-Alkylation of Pyrroles

Contributor(s): Timothy M. Swager, Shuang Liu
T. Tsuchimoto*, M. Igarashi, K. Aoki
Meiji University, Kawasaki, Japan
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Publikationsdatum:
22. September 2010 (online)

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Significance

Regioselective β-alkylation of ­pyrroles is achieved based on simple indium-­catalyzed reactions. Primary, secondary, and ­tertiary alkyl groups can be introduced by using readily available carbonyl compounds and nucleophiles. The reaction is proposed to proceed via the dipyrrolylalkane intermediate 5.