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Synfacts 2010(10): 1094-1094  
DOI: 10.1055/s-0030-1258624
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of Englerins A and B

Contributor(s): Steven V. Ley, Kimberley A. Roper
K. C. Nicolaou*, Q. Kang, S. Y. Ng, D. Y.-K. Chen*
Agency for Science, Technology and Research, Singapore
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Publication History

Publication Date:
22 September 2010 (online)

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Significance

Englerins A and B are guaiane sesquiterpenes that inhibit renal cancer cell growth with nanomolar potency. Enantioselective routes by Echavarren and Ma using a key gold-mediated cyclization (see: Synfacts 2010, 972; Synfacts 2010, 973) were recently published. This work is a formal enantioselective synthesis with a racemic synthesis completed from I.