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Synfacts 2010(9): 1027-1027  
DOI: 10.1055/s-0030-1257990
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Ni(II)-Catalyzed Asymmetric Aza-Ene-Type Reaction

Contributor(s): Hisashi Yamamoto, Zhi Li
K. Zheng, X. Liu, J. Zhao, Y. Yang, L. Lin, X. Feng*
Sichuan University, Chengdu, P. R. of China
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Publication History

Publication Date:
23 August 2010 (online)

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Significance

In this work, chiral N,N′-dioxide-nickel complexes were utilized in the catalytic aza-ene-type reaction between glyoxal derivatives and enamides or enecarbamates. Excellent enantio­selectivities up to >99% ee were obtained with relatively low catalyst loading (5 mol%).