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Synfacts 2010(9): 1048-1048  
DOI: 10.1055/s-0030-1257952
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Copper-Catalyzed Asymmetric Insertion into N-H Bonds

Contributor(s): Mark Lautens, David A. Candito
Z. Hou, J. Wang, P. He, J. Wang, B. Qin, X. Liu, L. Lin, X. Feng*
Sichuan University, Chengdu, P. R. of China
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Publication History

Publication Date:
23 August 2010 (online)

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Significance

The catalytic asymmetric insertion of metal carbenoids into heteroatom-hydrogen bonds has only recently been realized and there are few reports of efficient catalyst systems for this important transformation. The asymmetric insertion into N-H bonds is an especially important goal as chiral amines are often found in pharmaceutically useful compounds. The authors report a copper-catalyzed enantioselective insertion of metal carbenoids into N-H bonds of primary and secondary amines.