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Synfacts 2010(9): 1054-1054  
DOI: 10.1055/s-0030-1257905
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

Regioselective Functionalization of N-Benzenesulfonyl-3-bromopyrrole

Contributor(s): Paul Knochel, Thomas Kunz
T. Fukuda, T. Ohta, E.-i. Sudo, M. Iwao*
Nagasaki University, Japan
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Publikationsverlauf

Publikationsdatum:
23. August 2010 (online)

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Significance

A regioselective lithiation at the C2 position is reported. Subsequent reaction with reactive electrophiles leads to 2-functionalized pyrroles whereas less reactive electrophiles give 5-substituted pyrroles.