Amide-Directed sp^³ C-H Arylation

Significance

The CONHC₆F₅ amide group was shown to efficiently direct Csp^³-H arylation in both Pd(II)/Pd(IV) and Pd(0)/Pd(II) catalytic cycles. Thus, this opens a new efficient access to the C-H functionalization of aliphatic carboxylic acid derived substrates possessing α-hydrogen atoms.