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Synfacts 2010(8): 0851-0851  
DOI: 10.1055/s-0030-1257767
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of (±)-Clivonine

Contributor(s): Steven V. Ley, Catherine F. Carter
C. G. Mañas, V. L. Paddock, C. G. Bochet, A. C. Spivey*, A. J. P. White, I. Mann, W. Oppolzer
Imperial College London, GSK Tonbridge, UK; University of Fribourg and University of Geneva, Switzerland
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Publikationsdatum:
22. Juli 2010 (online)

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Significance

Clivonine is a lycorenine-type ­Amaryllidaceae alkaloid that was isolated from Clivia miniata in 1956 by Wildman. There has been one previous total synthesis reported by Irie in 1973 (J. Chem. Soc., Chem. Commun. 1973, 302).