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Kardiologie up2date 2011; 7(4): 257-268
DOI: 10.1055/s-0030-1257051
Hotline – Koronare Herzerkrankung und Atherosklerose

© Georg Thieme Verlag KG Stuttgart · New York

Antiatherogene Wirkung von High-Density-Lipoproteinen

Katherine  Sattler, Bodo  Levkau
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Publication Date:
02 February 2012 (online)

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Abstract

The heterogeneous plasma fraction of HDL-cholesterol (HDL-C) is the most important „endogenous negative“ risk factor for coronary artery disease. Although the primary target for therapy remains the reduction of LDL-C, HDL-C raising strategies may offer additional benefit. While prospective clinical studies are under way to test this issue, new pharmaceutical agents are currently being developed to effectively increase plasma HDL-C or improve HDL function. In this review, we discuss the latest developments in the field.

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Univ.-Prof. Dr. med. Bodo Levkau

Institut für Pathophysiologie
Zentrum für Innere Medizin
Universitätsklinikum Essen

Hufelandstraße 55
45122 Essen

Phone: 0201/723–4414

Email: levkau@uni-essen.de