ABSTRACT
Neurologic dysfunction is a common side effect of many chemotherapy drugs. For several
agents, neurotoxicity is common, severe, and can be dose-limiting. As the list of
newer chemotherapy agents and systemic “targeted therapies” grows, so does the number
and variety of potential neurotoxicities. This is a review of the clinical features
of chemotherapy-induced syndromes involving the central and peripheral nervous systems.
KEYWORDS
Chemotherapy adverse effects - polyneuropathy
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Edward J DropchoM.D.
Department of Neurology, Indiana University Medical Center
CL 292, Indianapolis, Indiana 46202
Email: edropcho@iupui.edu