Download PDF
Skull Base 2011; 21(1): 001-006
DOI: 10.1055/s-0030-1254406
ORIGINAL ARTICLE

© Thieme Medical Publishers

Salvage Treatment of Local Recurrence in Esthesioneuroblastoma: A Meta-analysis

Mitchell R. Gore1 , Adam M. Zanation1
  • 1Department of Otolaryngology, Head, and Neck Surgery, University of North Carolina Hospitals, North Carolina
Further Information

Publication History

Publication Date:
23 June 2010 (online)

    Permissions and Reprints

ABSTRACT

Esthesioneuroblastoma has a local recurrence rate of ~30%, but no standard regimen for salvage of local recurrence has been established. We report data from 678 patients from series published since 1990, with a risk reduction analysis of salvage with surgery, radiation, or combined surgery and radiation therapy. We found a 28.5% rate of local recurrence after treatment, and a 42.6% rate of successful salvage with surgery, radiation, or combined treatment. The odds ratio for successful salvage, defined as disease-free survival for at least 1 year, was not significantly different for combined surgery and radiation versus surgery alone or radiation alone or for surgery alone versus radiation alone. The salvage odds ratio for combined surgery and radiation therapy versus radiation therapy alone, 3.5, approached, but did not reach statistical significance. This study reveals a reasonable rate of successful salvage of local esthesioneuroblastoma recurrence using surgery, radiation, or combined surgery and radiation.

KEYWORDS

Esthesioneuroblastoma - salvage - sinus - nasal cavity - olfactory neuroblastoma

REFERENCES

  • 1 Dias F L, Sa G M, Lima R A et al.. Patterns of failure and outcome in esthesioneuroblastoma.  Arch Otolaryngol Head Neck Surg. 2003;  129 (11) 1186-1192
    CrossrefPubMedGoogle Scholar
  • 2 Ferlito A, Micheau C. Infantile olfactory neuroblastoma. A clinicopathological study with review of the literature.  ORL J Otorhinolaryngol Relat Spec. 1979;  41 (1) 40-45
    CrossrefPubMedGoogle Scholar
  • 3 Bradley P J, Jones N S, Robertson I. Diagnosis and management of esthesioneuroblastoma.  Curr Opin Otolaryngol Head Neck Surg. 2003;  11 (2) 112-118
    CrossrefPubMedGoogle Scholar
  • 4 Berger L, Luc G, Richard D. L'esthésioneuroépithéliome olfactif.  Bull Assoc Fr Etud Cancer. 1924;  13 410-421
    PubMedGoogle Scholar
  • 5 Unger F, Haselsberger K, Walch C, Stammberger H, Papaefthymiou G. Combined endoscopic surgery and radiosurgery as treatment modality for olfactory neuroblastoma (esthesioneuroblastoma).  Acta Neurochir (Wien). 2005;  147 (6) 595-601 discussion 601-602
    CrossrefPubMedGoogle Scholar
  • 6 Lund V J, Howard D, Wei W, Spittle M. Olfactory neuroblastoma: past, present, and future?.  Laryngoscope. 2003;  113 (3) 502-507
    CrossrefPubMedGoogle Scholar
  • 7 Morita A, Ebersold M J, Olsen K D, Foote R L, Lewis J E, Quast L M. Esthesioneuroblastoma: prognosis and management.  Neurosurgery. 1993;  32 (5) 706-714 discussion 714-715
    CrossrefPubMedGoogle Scholar
  • 8 Koka V N, Julieron M, Bourhis J et al.. Aesthesioneuroblastoma.  J Laryngol Otol. 1998;  112 (7) 628-633
    PubMedGoogle Scholar
  • 9 Theilgaard S A, Buchwald C, Ingeholm P, Kornum Larsen S, Eriksen J G, Sand Hansen H. Esthesioneuroblastoma: a Danish demographic study of 40 patients registered between 1978 and 2000.  Acta Otolaryngol. 2003;  123 (3) 433-439
    CrossrefPubMedGoogle Scholar
  • 10 Skarsgard D P, Groome P A, Mackillop W J et al.. Cancers of the upper aerodigestive tract in Ontario, Canada, and the United States.  Cancer. 2000;  88 (7) 1728-1738
    CrossrefPubMedGoogle Scholar
  • 11 Foote R L, Morita A, Ebersold M J et al.. Esthesioneuroblastoma: the role of adjuvant radiation therapy.  Int J Radiat Oncol Biol Phys. 1993;  27 (4) 835-842
    CrossrefPubMedGoogle Scholar
  • 12 Beitler J J, Fass D E, Brenner H A et al.. Esthesioneuroblastoma: is there a role for elective neck treatment?.  Head Neck. 1991;  13 (4) 321-326
    CrossrefPubMedGoogle Scholar
  • 13 Davis R E, Weissler M C. Esthesioneuroblastoma and neck metastasis.  Head Neck. 1992;  14 (6) 477-482
    CrossrefPubMedGoogle Scholar
  • 14 Bailey B J, Barton S. Olfactory neuroblastoma. Management and prognosis.  Arch Otolaryngol. 1975;  101 (1) 1-5
    CrossrefPubMedGoogle Scholar
  • 15 Argiris A, Dutra J, Tseke P, Haines K. Esthesioneuroblastoma: the Northwestern University experience.  Laryngoscope. 2003;  113 (1) 155-160
    CrossrefPubMedGoogle Scholar
  • 16 Monroe A T, Hinerman R W, Amdur R J, Morris C G, Mendenhall W M. Radiation therapy for esthesioneuroblastoma: rationale for elective neck irradiation.  Head Neck. 2003;  25 (7) 529-534
    CrossrefPubMedGoogle Scholar
  • 17 Dulguerov P, Allal A S, Calcaterra T C. Esthesioneuroblastoma: a meta-analysis and review.  Lancet Oncol. 2001;  2 (11) 683-690
    CrossrefPubMedGoogle Scholar
  • 18 Schmidt J L, Zarbo R J, Clark J L. Olfactory neuroblastoma: clinicopathologic and immunohistochemical characterization of four representative cases.  Laryngoscope. 1990;  100 (10 Pt 1) 1052-1058
    CrossrefPubMedGoogle Scholar
  • 19 Dulguerov P, Calcaterra T. Esthesioneuroblastoma: the UCLA experience 1970–1990.  Laryngoscope. 1992;  102 (8) 843-849
    CrossrefPubMedGoogle Scholar
  • 20 Sakata K, Aoki Y, Karasawa K et al.. Esthesioneuroblastoma. A report of seven cases.  Acta Oncol. 1993;  32 (4) 399-402
    CrossrefPubMedGoogle Scholar
  • 21 Zappia J J, Carroll W R, Wolf G T, Thornton A F, Ho L, Krause C J. Olfactory neuroblastoma: the results of modern treatment approaches at the University of Michigan.  Head Neck. 1993;  15 (3) 190-196
    CrossrefPubMedGoogle Scholar
  • 22 Guedea F, Van Limbergen E, Van den Bogaert W. High dose level radiation therapy for local tumour control in esthesioneuroblastoma.  Eur J Cancer. 1994;  30A (12) 1757-1760
    PubMedGoogle Scholar
  • 23 Slevin N J, Irwin C JR, Banerjee S S, Gupta N K, Farrington W T. Olfactory neural tumours—the role of external beam radiotherapy.  J Laryngol Otol. 1996;  110 (11) 1012-1016
    CrossrefPubMedGoogle Scholar
  • 24 Irish J, Dasgupta R, Freeman J et al.. Outcome and analysis of the surgical management of esthesioneuroblastoma.  J Otolaryngol. 1997;  26 (1) 1-7
    PubMedGoogle Scholar
  • 25 Levine P A, Gallagher R, Cantrell R W. Esthesioneuroblastoma: reflections of a 21-year experience.  Laryngoscope. 1999;  109 (10) 1539-1543
    CrossrefPubMedGoogle Scholar
  • 26 Pickuth D, Heywang-Köbrunner S H, Spielmann R P. Computed tomography and magnetic resonance imaging features of olfactory neuroblastoma: an analysis of 22 cases.  Clin Otolaryngol Allied Sci. 1999;  24 (5) 457-461
    PubMedGoogle Scholar
  • 27 Resto V A, Eisele D W, Forastiere A, Zahurak M, Lee D J, Westra W H. Esthesioneuroblastoma: the Johns Hopkins experience.  Head Neck. 2000;  22 (6) 550-558
    CrossrefPubMedGoogle Scholar
  • 28 Martel J, Darrouzet V, Duclos J Y, Bébéar J P, Stoll D. [Olfactory esthesioneuromas].  Rev Laryngol Otol Rhinol (Bord). 2000;  121 (4) 227-236
    PubMedGoogle Scholar
  • 29 Miyamoto R C, Gleich L L, Biddinger P W, Gluckman J L. Esthesioneuroblastoma and sinonasal undifferentiated carcinoma: impact of histological grading and clinical staging on survival and prognosis.  Laryngoscope. 2000;  110 (8) 1262-1265
    CrossrefPubMedGoogle Scholar
  • 30 Simon J H, Zhen W, McCulloch T M et al.. Esthesioneuroblastoma: the University of Iowa experience 1978-1998.  Laryngoscope. 2001;  111 (3) 488-493
    CrossrefPubMedGoogle Scholar
  • 31 Hwang S-K, Paek S-H, Kim D G, Jeon Y K, Chi J G, Jung H W. Olfactory neuroblastomas: survival rate and prognostic factor.  J Neurooncol. 2002;  59 (3) 217-226
    CrossrefPubMedGoogle Scholar
  • 32 Iliades T, Printza A, Eleftheriades N, Georgios K, Psifidis A, Thomas Z. Olfactory neuroblastoma. A report of 3 cases.  ORL J Otorhinolaryngol Relat Spec. 2002;  64 (6) 454-456
    CrossrefPubMedGoogle Scholar
  • 33 McLean J N, Nunley S R, Klass C, Moore C, Müller S, Johnstone P A. Combined modality therapy of esthesioneuroblastoma.  Otolaryngol Head Neck Surg. 2007;  136 (6) 998-1002
    CrossrefPubMedGoogle Scholar
  • 34 Loy A H, Reibel J F, Read P W et al.. Esthesioneuroblastoma: continued follow-up of a single institution's experience.  Arch Otolaryngol Head Neck Surg. 2006;  132 (2) 134-138
    CrossrefPubMedGoogle Scholar
  • 35 Eich H T, Müller R P, Micke O, Kocher M, Berthold F, Hero B. Esthesioneuroblastoma in childhood and adolescence. Better prognosis with multimodal treatment?.  Strahlenther Onkol. 2005;  181 (6) 378-384
    CrossrefPubMedGoogle Scholar
  • 36 Devaiah A K, Larsen C, Tawfik O, O'Boynick P, Hoover L A. Esthesioneuroblastoma: endoscopic nasal and anterior craniotomy resection.  Laryngoscope. 2003;  113 (12) 2086-2090
    CrossrefPubMedGoogle Scholar
  • 37 Eden B V, Debo R F, Larner J M et al.. Esthesioneuroblastoma. Long-term outcome and patterns of failure—the University of Virginia experience.  Cancer. 1994;  73 (10) 2556-2562
    CrossrefPubMedGoogle Scholar
  • 38 Chao K S, Kaplan C, Simpson J R et al.. Esthesioneuroblastoma, the impact of treatment modality.  Head Neck. 2001;  23 (9) 749-757
    CrossrefPubMedGoogle Scholar
  • 39 Kumar M, Fallon R J, Hill J S, Davis M M. Esthesioneuroblastoma in children.  J Pediatric Hematol Oncol. 2002;  24 (16) 482-487
    CrossrefPubMedGoogle Scholar
  • 40 Morris J A, Gardner M J. Calculating confidence intervals for relative risks (odds ratios) and standardised ratios and rates.  Br Med J (Clin Res Ed). 1988;  296 (6632) 1313-1316
    CrossrefPubMedGoogle Scholar
  • 41 Dulguerov P, Allal A S. Nasal and paranasal sinus carcinoma: how can we continue to make progress?.  Curr Opin Otolaryngol Head Neck Surg. 2006;  14 (2) 67-72
    PubMedGoogle Scholar
  • 42 Diaz Jr E M, Johnigan III R H, Pero C et al.. Olfactory neuroblastoma: the 22-year experience at one comprehensive cancer center.  Head Neck. 2005;  27 (2) 138-149
    CrossrefPubMedGoogle Scholar

Adam M ZanationM.D. 

Department of Otolaryngology, Head, and Neck Surgery

CB#7070, UNC-Chapel Hill School of Medicine, Chapel Hill, NC 27599-7070

Email: azanatio@med.unc.edu

      >