RSS-Feed abonnieren
DOI: 10.1055/s-0030-1253418
© Georg Thieme Verlag KG Stuttgart · New York
The Effect of 6-Weeks of Aerobic Exercise Training on Serum Fetuin-A levels in Non-Diabetic Obese Women
Publikationsverlauf
received 08.12.2009
first decision 05.03.2010
accepted 15.04.2010
Publikationsdatum:
21. Mai 2010 (online)

Abstract
Emerging evidence suggests that fetuin-A, a liver-derived glycoprotein, represents an important factor in the pathophysiology of the metabolic syndrome, type 2 diabetes and cardiovascular disease. So far circulating fetuin-A was found to be increased in fatty liver disease, however, the precise mechanisms regulating fetuin-A expression and secretion are largely unknown. Here we assessed serum fetuin-A levels in 14 non-diabetic, obese women (BMI 36.5±1.5 kg/m2) before and after a 6-week aerobic exercise program. Despite decreasing waist circumference (from 114.9±3.5 to 112.3±3.2 cm; P=0.006) and body fat content (from 44.1±1.5% to 43.4±1.5%; P=0.022) regular exercise 3-times per week over a 6-week period did not affect serum fetuin-A levels (before vs. after: 0.440±0.018 vs. 0.440±0.014 μg/ml; P=0.767). Thus, our data provide evidence against a major role of exercise in the regulation of serum fetuin-A levels in non-diabetic obese women.
Key words
fetuin-A - obesity - aerobic exercise
References
- 1
Das SK, Saltzman E, McCrory MA. et al .
Energy expenditure is very high in extremely obese women.
J Nutr.
2004;
134
1412-1416
MissingFormLabel
- 2
Devries MC, Samjoo IA, Hamadeh MJ. et al .
Effect of endurance exercise on hepatic lipid content, enzymes, and adiposity in men
and women.
Obesity.
2008;
16
2281-2288
MissingFormLabel
- 3
Ellis KJ.
Selected body composition methods can be used in field studies.
J Nutr.
2001;
131
1589S-1595S
MissingFormLabel
- 4
Fiore CE, Celotta G, Politi GG. et al .
Association of high alpha2-Heremans-Schmid glycoprotein/fetuin concentration in serum
and intima-media thickness in patients with atherosclerotic vascular disease and low
bone mass.
Atherosclerosis.
2007;
195
110-115
MissingFormLabel
- 5
Goele K, Bosy-Westphal A, Rumcker B. et al .
Influence of Changes in Body Composition and Adaptive Thermogenesis on the Difference
between Measured and Predicted Weight Loss in Obese Women.
Obes Facts.
2009;
2
105-109
MissingFormLabel
- 6
Ix JH, Wassel CL, Kanaya AM. et al .
Fetuin-A and incident diabetes mellitus in older persons.
JAMA.
2008;
300
182-188
MissingFormLabel
- 7
Matthews DR, Hosker JP, Rudenski AS. et al .
Homeostasis model assessment: insulin resistance and beta-cell function from fasting
plasma glucose and insulin concentrations in man.
Diabetologia.
1985;
28
412-419
MissingFormLabel
- 8
Mori K, Emoto M, Araki T. et al .
Effects of pioglitazone on serum fetuin-A levels in patients with type 2 diabetes
mellitus.
Metabolism.
2008;
57
1248-1252
MissingFormLabel
- 9
Mori K, Emoto M, Araki T. et al .
Association of serum fetuin-A with carotid arterial stiffness.
Clin Endocrinol.
2007;
66
246-250
MissingFormLabel
- 10
Mori K, Emoto M, Yokoyama H. et al .
Association of serum fetuin-A with insulin resistance in type 2 diabetic and nondiabetic
subjects.
Diabetes Care.
2006;
29
468
MissingFormLabel
- 11
Reinehr T, Roth CL.
Fetuin-A and its relation to metabolic syndrome and fatty liver disease in obese children
before and after weight loss.
J Clin Endocrinol Metab.
2008;
93
4479-4485
MissingFormLabel
- 12
Stefan N, Fritsche A, Weikert C. et al .
Plasma fetuin-A levels and the risk of type 2 diabetes.
Diabetes.
2008;
57
2762-2767
MissingFormLabel
- 13
Stefan N, Hennige AM, Staiger H. et al .
Alpha2-Heremans-Schmid glycoprotein/fetuin-A is associated with insulin resistance
and fat accumulation in the liver in humans.
Diabetes Care.
2006;
29
853-857
MissingFormLabel
- 14
Weikert C, Stefan N, Schulze MB. et al .
Plasma fetuin-a levels and the risk of myocardial infarction and ischemic stroke.
Circulation.
2008;
118
2555-2562
MissingFormLabel
Correspondence
B. SchultesMD
Interdisciplinary Obesity Center
Kantonsspital St. Gallen
Heidener Straße 11
9400 Rorschach
Switzerland
Telefon: +41/071/858 36 24
Fax: +41/071/858 36 29
eMail: bernd.schultes@kssg.ch