Platelet-Derived Chemokines in Vascular Remodeling and Atherosclerosis

Rory R Koenen; Christian Weber

doi:10.1055/s-0030-1251500

Seminars in Thrombosis and Hemostasis, Inhaltsverzeichnis

Semin Thromb Hemost 2010; 36(2): 163-169
DOI: 10.1055/s-0030-1251500

Platelet-Derived Chemokines in Vascular Remodeling and Atherosclerosis

Rory R. Koenen¹ ^, ² , Christian Weber¹ ^, ²

¹Institute for Molecular Cardiovascular Research, University Hospital Aachen, Medical Faculty, Rheinisch-Westfälische Technische Hochschule, Aachen, Germany
²Cardiovascular Research Institute Maastricht, University Maastricht, Maastricht, The Netherlands

Abstract

ABSTRACT

During the past decade it has become increasingly clear that platelets exert important functions in the context of inflammation, beyond their role in hemostasis. Platelets may adhere to intact endothelial cells and promote local vascular inflammation by recruiting leukocytes via direct interactions or by secreting inflammatory mediators such as chemokines. Accordingly, platelet-derived chemokines play a crucial role in directing leukocytes to sites of vascular injury or dysfunction, thereby contributing to neointimal hyperplasia or atherosclerosis. In this review, we discuss the function of platelets as immune cells that potentiate vascular inflammation with a special focus on platelet-derived chemokines: their effects and interactions and their potential quality as targets for the treatment and/or prevention of cardiovascular disease.

KEYWORDS

Platelets - chemokines - endothelium - vascular inflammation

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Referenzen

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Dr. Rory R KoenenPh.D.

Institute for Molecular Cardiovascular Research, Universitätsklinikum Aachen, Rheinisch-Westfälische Technische Hochschule

Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany

eMail: rkoenen@ukaachen.de