Comparative X‐Ray and Conformational Analysis of a New Crystal of 13α,21-Dihydroeurycomanone with Eurycomanone from Eurycoma longifolia and Their Anti-Estrogenic Activity Using the Uterotrophic Assay

Abstract

13α,21-Dihydroeurycomanone (1), a known quassinoid of Eurycoma longifolia Jack was recrystallized from chloroform into a novel crystal structure in space group P2₁. Its X‐ray data were compared with those of eurycomanone (2). Following intraperioneal injections at similar doses of 2.44 µmol/kg/day for 3 consecutive days, 2 displayed comparable potency with tamoxifen but was more potent than 1 in the anti-estrogenic effect against 17α-ethynylestradiol (EE)-induced uterotrophy of immature rats.

Eurycoma longifolia - Simaroubaceae - 13α,21‐dihydroeurycomanone - eurycomanone - X‐ray - conformational analysis - anti‐uterotrophic activity

References

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