Highly Oxygenated Guaianolides from Artemisia dubia

Abstract

Investigation of a Chinese folk medicine, Artemisia dubia (syn. Artemisia subdigitata), has resulted in the isolation of eight new guaianolides (artemdubolides A–H, 1–8), and nineteen known sesquiterpene lactones. Their structures were elucidated primarily on the basis of spectroscopic methods, including extensive 2D NMR experiments. The cytotoxic activities of compounds 1–8 were evaluated against A549 (human lung adenocarcinoma), Colo205 (human colon carcinoma), HepG2 (human hepatoma), and MDA‐MB‐435 (human melanoma) cell lines. Compounds 2 and 5 showed weak cell growth inhibition of Colo205 and MDA‐MB‐435 cells.

Key words

Artemisia dubia - Asteraceae - guaianolides - artemdubolides A–H - cytotoxic activities - sesquiterpene lactones

References

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