Subscribe to RSS
DOI: 10.1055/s-0030-1249946
Infektionen mit den equinen Herpesviren vom Typ 1 und 4
Publication History
Publication Date:
17 June 2010 (online)



Infektionen mit EHV-1 und EHV-4 zählen zu den wichtigsten viralen Pferdekrankheiten. Während EHV-1 regelmäßig systemische Infektionen verursacht und neben meist milden respiratorischen Erkrankungen auch häufiger zu Aborten trächtiger Tiere und zur herpesviralen Enzephalomyelopathie führt, bleibt EHV-4 in der Regel auf den Respirationstrakt beschränkt. Der Nachweis gelingt im Nasensekret mittels Virusanzucht oder Nachweis der viralen DNA durch PCR-Verfahren. Zur serologischen Diagnose wird zumeist der Serumneutralisationstest eingesetzt, der jedoch keine Differenzierung von EHV-1- und EHV-4-Infektion erlaubt. Ein Serumpaar ist geeignet, eine kürzlich stattgehabte Infektion zu diagnostizieren.
-
Literatur
- 1 Allen G, Yeargan M, Costa LR, Cross R. Major histocompatibility complex class I-restricted
cytotoxic T-lymphocyte responses in horses infected with equine herpesvirus 1. J Virol
1995; 69: 606-612
MissingFormLabel
- 2 Allen GP, Bryans JT. Molecular epizootiology, pathogenesis, and prophylaxis of equine
herpesvirus-1 infections. Prog Vet Microbiol Immunol 1986; 2: 78-144
MissingFormLabel
- 3 Allen GP, Bolin DC, Bryant U, Carter CN, Giles RC, Harrison LR, Hong CB, Jackson
CB, Poonacha K, Wharton R, Williams NM. Prevalence of latent, neuropathogenic equine
herpesvirus-1 in the thoroughbred broodmare population of central Kentucky. Equine
Vet J 2008; 40: 105-110
MissingFormLabel
- 4 Breathnach CC, Yeargan MR, Sheoran AS, Allen GP. The mucosal humoral immune response
of the horse to infective challenge and vaccination with equine herpesvirus-1 antigens.
Equine Vet J 2001; 33: 651-657
MissingFormLabel
- 5 Crabb BS, MacPherson CM, Reubel GH, Browning GF, Studdert MJ, Drummer HE. A type-specific
serological test to distinguish antibodies to equine herpesviruses 4 and 1. Arch Virol
1995; 140: 245-258
MissingFormLabel
- 6 Foote CE, Love DN, Gilkerson JR, Whalley JM. Serological responses of mares and weanlings
following vaccination with an inactivated whole virus equine herpesvirus 1 and equine
herpesvirus 4 vaccine. Vet Microbiol 2002; 88: 13-25
MissingFormLabel
- 7 Foote CE, Love DN, Gilkerson JR, Whalley JM. Detection of EHV-1 and EHV-4 DNA in
unweaned thoroughbred foals from vaccinated mares on a large stud farm. Equine Vet
J 2004; 36: 341-345
MissingFormLabel
- 8 Goodman LB, Wagner B, Flaminio MJ, Sussman KH, Metzger SM, Holland R, Osterrieder
N. Comparison of the efficacy of inactivated combination and modified-live virus vaccines
against challenge infection with neuropathogenic equine herpesvirus type 1 (EHV-1).
Vaccine 2006; 24: 3636-3645
MissingFormLabel
- 9 Goodman LB, Loregian A, Perkins GA, Nugent J, Buckles EL, Mercorelli B, Kydd JH,
Palu G, Smith KC, Osterrieder N, Davis-Poynter N. A point mutation in a herpesvirus
polymerase determines neuropathogenicity. PLoS Pathog 2007; 3: e160
MissingFormLabel
- 10 Hubert PH, Birkenmaier S, Rziha HJ, Osterrieder N. Alterations in the equine herpesvirus
type-1 (EHV-1) strain RacH during attenuation. Zentralbl Veterinarmed [B] 1996; 43:
1-14
MissingFormLabel
- 11 Lunn DP, Davis-Poynter N, Flaminio MJ, Horohov DW, Osterrieder K, Pusterla N, Townsend
HG. Equine herpesvirus-1 consensus statement. J Vet Intern Med 2009; 23: 450-461
MissingFormLabel
- 12 Mumford JA, Rossdale PD, Jessett DM, Gann SJ, Ousey J, Cook RF. Serological and virological
investigations of an equid herpesvirus 1 (EHV-1) abortion storm on a stud farm in
1985. J Reprod Fertil Suppl 1987; 35: 509-518
MissingFormLabel
- 13 Osterrieder N, de Walle GR Van. Pathogenic potential of equine alphaherpesviruses:
The importance of the mononuclear cell compartment in disease outcome. Vet Microbiol
2010; (im Druck)
MissingFormLabel
- 14 Osterrieder N, Neubauer A, Brandmuller C, Kaaden OR, O'Callaghan DJ. The equine herpesvirus
1 IR6 protein influences virus growth at elevated temperature and is a major determinant
of virulence. Virology 1996; 226: 243-251
MissingFormLabel
- 15 Paillot R, Daly JM, Juillard V, Minke JM, Hannant D, Kydd JH. Equine interferon gamma
synthesis in lymphocytes after in vivo infection and in vitro stimulation with EHV-1.
Vaccine 2005; 23: 4541-4551
MissingFormLabel
- 16 Patel JR, Bateman H, Williams J, Didlick S. Derivation and characterisation of a
live equid herpes virus-1 (EHV-1) vaccine to protect against abortion and respiratory
disease due to EHV-1. Vet Microbiol 2003; 91: 23-39
MissingFormLabel
- 17 Patel JR, Didlick S, Bateman H. Efficacy of a live equine herpesvirus-1 (EHV-1) strain
C147 vaccine in foals with maternally-derived antibody: protection against EHV-1 infection.
Equine Vet J 2004; 36: 447-451
MissingFormLabel
- 18 Patel JR, Heldens J. Equine herpesviruses 1 (EHV-1) and 4 (EHV-4) – epidemiology,
disease and immunoprophylaxis: a brief review. Vet J 2005; 170: 14-23
MissingFormLabel
- 19 Perkins GA, Goodman LB, Dubovi EJ, Kim SG, Osterrieder N. Detection of equine herpesvirus-1
in nasal swabs of horses by quantitative real-time PCR. J Vet Intern Med 2008; 22:
1234-1238
MissingFormLabel
- 20 Pusterla N, Leutenegger CM, Wilson WD, Watson JL, Ferraro GL, Madigan JE. Equine
herpesvirus-4 kinetics in peripheral blood leukocytes and nasopharyngeal secretions
in foals using quantitative real-time TaqMan PCR. J Vet Diagn Invest 2005; 17: 578-581
MissingFormLabel
- 21 Pusterla N, Hussey SB, Mapes S, Leutenegger CM, Madigan JE, Ferraro GL, Wilson WD,
Lunn DP. Comparison of four methods to quantify equid herpesvirus 1 load by real-time
polymerase chain reaction in nasal secretions of experimentally and naturally infected
horses. J Vet Diagn Invest 2009; 21: 836-840
MissingFormLabel
- 22 Rosas CT, Goodman LB, Einem J von, Osterrieder N. Equine herpesvirus type 1 modified
live virus vaccines: quo vaditis?. Expert Rev Vaccines 2006; 5: 119-131
MissingFormLabel
- 23 Slater JD, Lunn DP, Horohov DW, Antczak DF, Babiuk L, Breathnach C, Chang YW, Davis-Poynter
N, Edington N, Ellis S, Foote C, Goehring L, Kohn CW, Kydd J, Matsumura T, Minke J,
Morley P, Mumford J, Neubauer T, O'Callaghan D, Osterrieder K, Reed S, Smith K, Townsend
H, der Meulen K van, Whalley M, Wilson WD. Report of the equine herpesvirus-1 Havermeyer
Workshop, San Gimignano, Tuscany, June 2004. Vet Immunol Immunopathol 2006; 111: 3-13
MissingFormLabel
- 24 Smith KC, Mumford JA, Lakhani K. A comparison of equid herpesvirus-1 (EHV-1) vascular
lesions in the early versus late pregnant equine uterus. J Comp Pathol 1996; 114:
231-247
MissingFormLabel
- 25 Smith KC, Borchers K. A study of the pathogenesis of equid herpesvirus-1 (EHV-1)
abortion by DNA in-situ hybridization. J Comp Pathol 2001; 125: 304-310
MissingFormLabel
- 26 Tearle JP, Smith KC, Platt AJ, Hannant D, Davis-Poynter NJ, Mumford JA. In vitro
characterisation of high and low virulence isolates of equine herpesvirus-1 and − 4.
Res Vet Sci 2003; 75: 83-86
MissingFormLabel
- 27 Telford EA, Watson MS, Perry J, Cullinane AA, Davison AJ. The DNA sequence of equine
herpesvirus-4. J Gen Virol 1998; , 79 (Pt 5) 1197-1203
MissingFormLabel
- 28 University of Kentucky, Gluck Equine Research Center Diseases of the horse caused
by equine herpesvirus type 1 (EHV-1) – a bibliography of source materials. Im Internet:.
http://www.ca.uky.edu/gluck/images/info%2520pages/ehv1/ehv5703Large.jpg Stand: 10.05.2010
MissingFormLabel