Planta Med 2010; 76(16): 1910-1914
DOI: 10.1055/s-0030-1249936
Natural Product Chemistry
Letters
© Georg Thieme Verlag KG Stuttgart · New York

Cytotoxic Chaetoglobosins from the Endophyte Chaetomium globosum

Jie Zhang1 , Hui Ming Ge1 , Rui Hua Jiao1 , Jing Li1 , Hui Peng1 , Yu Rong Wang1 , Jun Hua Wu1 , Yong Chun Song1 , Ren Xiang Tan1
  • 1Institute of Functional Biomolecules, State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing, China
Further Information

Publication History

received February 4, 2010 revised March 28, 2010

accepted April 16, 2010

Publication Date:
19 May 2010 (online)

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Abstract

Two new alkaloids chaetoglobosins V (1) and W (2), together with the six known congeners 38, were isolated through bioassay-guided fractionations from the EtOAc extract of a solid culture of Chaetomium globosum IFB-E041. The structures were elucidated by spectroscopic methods including mainly 1D and 2D NMR techniques. Chaetoglobosin W (2) was unique in its possession of an oxolane ring formed via an oxygen bridge between C-3 and C-6. The isolated fungal metabolites exhibited moderate cytotoxic activities against four human cancer cell lines (KB, K562, MCF-7, and HepG2) with their IC50 values in a range of 18–30 µg/mL.

References

Prof. Dr. Ren Xiang Tan

Institute of Functional Biomolecules
State Key Laboratory of Pharmaceutical Biotechnology
Nanjing University

22 Hankou Road

Nanjing 210093

People's Republic of China

Phone: + 86 25 83 59 29 45

Fax: + 86 25 83 30 27 28

Email: rxtan@nju.edu.cn