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DOI: 10.1055/s-0029-1245132
© Georg Thieme Verlag KG Stuttgart · New York
Bedeutung des nukleären Faktors kappaB für das primäre Offenwinkelglaukom – eine Hypothese
Importance of the Nuclear Factor KappaB for the Primary Open Angle Glaucoma –a HypothesisPublikationsverlauf
Eingegangen: 23.11.2009
Angenommen: 8.1.2010
Publikationsdatum:
12. Februar 2010 (online)

Zusammenfassung
Das primäre Offenwinkelglaukom (POWG) ist eine multifaktoriell bedingte Optikusneuropathie, die durch viele verschiedene Risikofaktoren begünstigt wird. Einige der Risikofaktoren wirken sich auf den Transkriptionsfaktor NF-κB aus, ein Kernprotein, das an spezifische DNS-Abschnitte bindet und zahlreiche Gene beeinflussen kann. Durch einen erhöhten Augeninnendruck, ein erhöhtes Lebensalter, vaskuläre Störungen und durch einen erhöhten oxidativen Streß kann NF-κB aktiviert werden. Denkbar ist eine Überstimulation von NF-κB beim POWG mit der Folge zahlreicher biochemischer Entgleisungen. Durch Augendrucksenkung, aber auch durch die Therapie mit Statinen, omega-3-Fettsäuren sowie mit α-Liponsäure kann NF-κB gehemmt und somit positiv auf das POWG Einfluss genommen werden. Dieses Modell ist eine Hypothese und möchte als Grundlage für Diskussionen dienen.
Abstract
The primary open-angle glaucoma (POAG) is an optic neuropathy which is influenced by a number of different risk factors. Some of them can induce the transcriptional factor NF-κB, a nuclear protein which binds to specific areas of the DNA to stimulate different genes. NF-κB can be activated by increased intraocular pressure, increased age, vascular diseases and by oxidative stress. In the case of POAG NF-κB might be overstimulated with the induction of uncontrolled biochemical reactions. Treatment strategies for reducing NF-κB are to reduce intraocular pressure as well as therapies with statins, omega-3-fatty acids and α-lipoic acid. This model is a hypothesis and is intende to provide a basis for further discussions and basic research.
Schlüsselwörter
NF-κB - Glaukom - oxidativer Stress - Endothelin-1
Key words
NF-κB - glaucoma - oxidative stress - endothelin-1
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Prof. Dr. Carl Erb
Abteilung für Augenheilkunde, Schlosspark-Klinik
Heubnerweg 2
14059 Berlin
Telefon: ++ 49/30/32 64 12 51
Fax: ++ 49/30/32 64 12 57
eMail: carl.erb@schlosspark-klinik.de
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