Semin Thromb Hemost 2009; 35(8): 806-813
DOI: 10.1055/s-0029-1245113
© Thieme Medical Publishers

Recent Improvements in the Clinical Treatment of Coagulation Factor Inhibitors

Massimo Franchini1 , 2 , Giuseppe Lippi2 , 3
  • 1Immunohematology and Transfusion Center, University Hospital of Parma, Parma, Italy
  • 2Department of Pathology and Laboratory Medicine, University Hospital of Parma, Parma, Italy
  • 3Clinical Chemistry Laboratory, University Hospital of Parma, Parma, Italy
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Publication History

Publication Date:
18 February 2010 (online)

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ABSTRACT

The mainstay of therapy in patients with congenital hemophilia is factor replacement. However, the development of inhibitors in these patients is a major complication that represents an important challenge in hemophilia care. Development of inhibitors complicates the clinical course of severe hemophilia in up to 30% of patients with hemophilia A and up to 5% of patients with hemophilia B. Although the main short-term objective of the treatment of alloantibodies against factors VIIII and IX is to control the bleeding diathesis, the eradication of the inhibitor is the leading long-term goal. The management of severe bleeding episodes and the definitive eradication of the autoantibody are also the two main options of the clinical management of patients with acquired hemophilia, a rare but life-threatening hemorrhagic condition. The most recent options available for treating patients with acquired hemophilia and congenital hemophilia with inhibitors are addressed in this review.

REFERENCES

Massimo FranchiniM.D. 

Immunohematology and Transfusion Center, Department of Pathology and Laboratory Medicine

University Hospital of Parma, Parma, Italy

Email: mfranchini@ao.pr.it