Planta Med 2010; 76(7): 653-661
DOI: 10.1055/s-0029-1240898
Reviews
© Georg Thieme Verlag KG Stuttgart · New York

Plectranthus barbatus: A Review of Phytochemistry, Ethnobotanical Uses and Pharmacology – Part 1

Rawiya H. Alasbahi1 , Matthias F. Melzig2
  • 1Faculty of Pharmacy, Department of Pharmacognosy, University of Aden, Crater-Aden, Yemen
  • 2Institute of Pharmacy, Free University Berlin, Berlin, Germany
Further Information

Prof. Dr. Matthias F. Melzig

Institute of Pharmacy
Free University Berlin

Königin-Luise-Str. 2 + 4

14195 Berlin

Germany

Phone: + 49 30 83 85 14 51

Fax: + 49 30 83 85 14 61

Email: melzig@zedat.fu-berlin.de

Publication History

received May 19, 2009 revised Dec. 7, 2009

accepted January 25, 2010

Publication Date:
22 February 2010 (online)

Table of Contents #

Abstract

Plectranthus barbatus Andr. is one of the most important species of the genus Plectranthus L′ Herit. (Lamiaceae), with a wide variety of traditional medicinal uses in Hindu and Ayurvedic traditional medicine as well as in the folk medicine of Brazil, tropical Africa and China. The plant has therefore been an attractive target for intensive chemical and pharmacological studies up to now. This review presents data about the phytochemistry, ethnobotanical uses and pharmacology of Plectranthus barbatus as well as the pharmacology of its constituents. In addition to essential oil, abietane diterpenoids and 8,13-epoxy-labd-14-en-11-one diterpenoids are the main constituents found in Plectranthus barbatus. The major ethnobotanical uses are for intestinal disturbance and liver fatigue, respiratory disorders, heart diseases and certain nervous system disorders. Forskolin as one of the major constituents with its unique adenylyl cyclase activation that underlies the wide range of pharmacological properties could explain the different traditional uses of Plectranthus barbatus. Forskolin is involved in a number of patented pharmaceutical preparations used as over-the-counter drugs for the treatment of several ailments. However, the water-insoluble nature of forskolin limits its clinical usefulness. Forskolin thus served as a prototype for the development of 6-(3-dimethylaminopropionyl)forskolin hydrochloride (NKH477) as a potent water-soluble forskolin derivative that finds use in the therapy for a number of diseases especially of the cardiovascular system.

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Introduction

Plectranthus L′ Herit., is a complex genus of the family Lamiaceae (Labiatae) that contains about 300 species distributed in tropical Africa, Asia and Australia [1]. Taxonomically the genera Coleus and Plectranthus are recombined by the Japanese authors to the genus Plectranthus [2]. One of the most important species of this genus is Plectranthus barbatus Andr., which is commonly referred to by a number of synonyms such as Plectranthus forskohlii Briq, Plectranthus forskalaei Willd., Plectranthus kilimandschari (Gürke) H. L. Maass., Plectranthus grandis (Cramer) R. H. Willemse, Coleus forskohlii Briq., Coleus kilimandschari Gürke ex Engl., Coleus coerulescens Gürke, Coleus comosus A. Rich., and Coleus barbatus (Andr.) Benth [1]. Plectranthus barbatus grows perennially over the tropical and subtropical regions of the Indian subcontinent and is cultivated commercially for its use in pickles. It is also distributed over parts of Pakistan, Sri Lanka, tropical East Africa, Asia (South of Arabian Peninsula, China) and Brazil [3], [4], [5].

P. barbatus is one of the most commonly used medicinal species of the genus Plectranthus. A diversity of traditional medicinal uses of P. barbatus in India (Hindu and Ayurvedic medicine), East and Central Africa, China, and Brazil have been reported. The majority of uses are for intestinal disturbance and liver fatigue, respiratory disorders, heart diseases and certain central nervous system disorders [1], [3], [4], [6], [7]. P. barbatus root extracts, such as the 50 % ethanolic and methanolic extracts were therefore, in the middle of the 1970s, independently involved in screening programs for biological activities such as cardiovascular properties in the Central Drug Research Institute (CDRI), Lucknow, India, and by the group at Hoechst India Limited in Bombay, India. Reports from both research groups revealed the hypotensive and antispasmodic effects of the root extracts as well as the isolation of the major active principle which was named coleonol by CDRI [6], [8], [9], and forskolin (26) (see [Fig. 2]) by Hoechst India Limited [5], [10]. Subsequent chemical analysis and NMR spectral studies revealed the identity of both compounds [11], [12], [13]. Additionally, a great number of constitutes of P. barbatus were isolated and the pharmacology of some of them was unraveled.

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Fig. 1 Abietane diterpenoids.

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Fig. 2 8,13-Epoxylabd-14-en-11-one diterpenoids.

The unique ability of forskolin (26) to stimulate adenylyl cyclase directly, not through β-adrenoreceptors, in different broken cell preparations as well as in intact tissues, with a consequently increasing level of adenosine 3′,5′-cyclic monophosphate (cAMP) [5], [14], still motivates a great deal of scientific investigations of forskolin, forskolin derivatives and other constituents of P. barbatus. The biological profile, mechanism of action as well as the biochemical properties of forskolin have been revealed through a great number of studies worldwide. Although forskolin has been used in diverse studies for over 30 years, it will most likely continue to be an important tool to study the variety of cellular processes.

Due to the importance of P. barbatus in traditional medicine and as a source of forskolin, a general adenylyl cyclase activator with a great variety of pharmacological effects, the increasing use of the plant extracts standardized with certain amounts of forskolin as well as forskolin as over-the-counter drugs in spite of its clinical uselessness because of its nonspecific general activation of adenyly cyclase and low water solubility, and the distribution of information regarding P. barbatus under a number of synonymous Latin names, the purpose of this review is to provide data about the phytochemistry, ethnobotanical uses and pharmacology of P. barbatus and its major constituents such as forskolin (26) (see [Fig. 2]) and to delineate the potential of forskolin for the development of the novel water-soluble forskolin derivate, the 6-(3-dimethylaminopropionyl)forskolin hydrochloride (NKH477) (79) (see [Fig. 7]) as a substantial therapeutic agent.

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Fig. 3 8,13-Epoxylabdane diterpenoids with some changes from the basic structure.

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Fig. 4 Miscellaneous labdane diterpenoids.

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Fig. 5 8,13-Epoxylabd-14-en-11-one diterpene glycosides.

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Fig. 6 Miscellaneous constituents.

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Fig. 7 6-(3-Dimethylaminopropionyl)-forskolin hydrochloride (NKH477).

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Phytochemistry

P. barbatus, especially that grown in India, Brazil, East Africa (Kenya) and China has been an attractive target for intensive chemical and pharmacological studies for novel biologically active constituents. The main constituents isolated from different parts of P. barbatus are diterpenoids and essential oil.

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Diterpenoids

Two main groups of diterpenoids, the abietane diterpenoids (abietanoids) and the 8,13-epoxy-labd-14-en-11-one diterpenoids were identified in P. barbatus. [Table 1] demonstrates the diterpenoids isolated from different parts of P. barbatus. Although the majority of abietane diterpenoids were isolated from the leaves and stems of P. barbatus growing in Brazil and from the leaves of P. barbatus distributed in East Africa (Kenya), some of them were also obtained from the leaves, roots and whole plant as well as from the roots of P. barbatus growing in China and India respectively ([Table 1]). The identified abietanoids are of various structures which could be classified accordingly into royleanones {(+)-allylroyleanone (1) [15] and coleon S (2) [16], [17]}, spirocoleons {coleon O (3) [18], coleon T (4) [16], [17], plectrin (5) [15], [18], barbatusin (6) [7], [19], [20], 3β-hydroxy-3-deoxybarbatusin (7) [7], cyclobutatusin (8) [7], [19], [21] and 7β-acetyl-12-deacetoxycyclobutatusin (9) [19]}, vinylogous quinones (also named quinone methides) {(16R)-coleon E (10) [15], [22] and coleon F (11) [15], [23]}, acylhydroquinones {(16R)-plectrinon A (12) [3], [15], plectrinon B (13) [15], 14-deoxycoleon U (14) [24] and coleon C (15) [25]}, 6,7-secoabietanoids {6,7-secoabietane diterpene I (16), 6,7-secoabietane diterpene II (17) [26] and cariocal (18) [27]}, aromatic abietanoids such as abietatriene (19) [28], phenolic abietanoids {demethylcryptojaponol (20) [24], ferruginol (21) [29], sugiol (22) [30], 20-deoxocarnosol (23) [31], [32] and 6β-hydroxycarnosol (24) [33]}, including that with a rearranged abietane skeleton {barbatusol (25) [29]} ([Fig. 1]).

Table 1 Diterpenoids isolated from Plectranthus barbatus.

No. of the compound

Name of the compound

Parta used

P. barbatus location

References

Abietane diterpenoids

1

(+)-Allylroyleanone (plectranthone J)

L

East Africa – Kenya

[15]

2

Coleon S

L

China

[16], [17]

3

Coleon O

L

East Africa – Kenya

[18]

4

Coleon T

L

China

[16], [17]

5

Plectrin

L

East Africa – Kenya

[15], [18]

6

Barbatusin

L

Brazil

[7], [19], [20]

7

3β-Hydroxy-3-deoxybarbatusin

L

Brazil

[7]

8

Cyclobutatusin

L

Brazil

[7], [19], [21]

9

7β-Acetyl-12-deacetoxycyclobutatusin

L

Brazil

[19]

10

(16R)-Coleon E

L

East Africa – Kenya

[15], [22]

11

Coleon F

L

East Africa – Kenya

[15], [23]

12

(16R)-Plectrinon A

L

Brazil, East Africa – Kenya

[3], [15]

13

Plectrinon B

L

East Africa – Kenya

[15]

14

14-Deoxycoleon U

R

China

[24]

15

Coleon C

WP

China

[25]

16

6,7-Secoabietane diterpene I

S

Brazil

[26]

17

6,7-Secoabietane diterpene II

S

Brazil

[26]

18

Cariocal

S

Brazil

[27]

19

Abietatriene (dehydroabietane)

R

India

[28]

20

Demethylcryptojaponol (11-hydroxysugiol)

R

China

[24]

21

Ferruginol

S

Brazil

[29]

22

Sugiol

WP

China

[30]

23

20-Deoxocarnosol

S

Brazil

[31], [32]

24

6β-Hydroxycarnosol

S

Brazil

[33]

25

Barbatusol

S

Brazil

[29]

8,13-Epoxylabd-14-en-11-one-diterpenoids

26

Forskolin (7β-acetoxy-1α,6β,9α-trihydroxy-8,13-epoxy-labd-14-en-11-one; coleonol; colforsin; 1-deacetylforskolin B, 6-deacetylforskolin J)

R, R

India, China

[5], [10], [34], [35], [36], [37]

27

9-Deoxyforskolin (7β-acetoxy-1α,6β-dihydroxy-8,13-epoxy-labd- 14-en-11-one)

R

India

[5], [35], [38]

28

1,9-Dideoxyforskolin (7β-acetoxy-6β-hydroxy-8,13-epoxy-labd-14-en-11-one)

R

India

[5], [10], [35]

29

1,9 Dideoxy-7-deacetylforskolin (6β,7β-dihydroxy-8,13-epoxy-labd-14-en-11-one)

R

India

[5], [10], [35]

30

Deacetyl-1-deoxyforskolin (6β,7β,9α- trihydroxy-8,13-epoxy-labd-14-en-l l- one)

R

India

[35]

31

6-Acetyl-1-deoxyforskolin

WP

China

[39]

32

6-Acetyl-1,9-dideoxyforskolin

WP

China

[39]

33

1,6-Di-O-acetylforskolin (1α,6β,7β triacetoxy-9α-hydroxy-8,13-epoxy-labd-14-en-11-one; forskolin A; 1,7-diaceylisoforskolin)

R, WP

China

[4], [40], [41]

34

1-Acetylforskolin (1α,7β-diacetoxy-6β, 9α-dihydroxy-8,13-epoxy-labd-14-en-11-one; forskolin B)

R, WP

China

[4], [40], [41]

35

Isoforskolin (6β-acetoxy-1α,7β,9α-trihydroxy-8,13-epoxy-labd-14-en-11-one; coleonol B; forskolin C; 1-deacetylforskolin I)

R, R, L, WP

India, China

[4], [10], [16], [37], [40], [41], [42], [43], [44], [45]

36

1,9-Dideoxycoleonol B (7β-hydroxy-6β-acetoxy-8,13-epoxy-labd-14-en-11-one)

R

India,

[46]

37

7-Deacetylforskolin (1α,6β,7β,9α-tetrahydroxy-8,13-epoxy-labd-14-en-11-one; deacetylforskolin; 6-deacetylisoforskolin; forskolin D)

R, R, WP

India, China

[4], [5], [10], [35], [40], [41]

38

Forskolin E (lα,7β-diacetoxy-6β-hydroxy-8,13-epoxy-labd-14-en-l1-one; 9-dehydroxyforskolin B)

R, WP

China

[4], [47]

39

Forskolin F (7β-acetoxy-6β,9α-dihydroxy-8,13-epoxy-labd-14-en-11-one; 1-deoxyforskolin; 1-deacetoxyforskolin B; coleonol D)

R, R, WP

India, China

[4], [35], [43], [47], [48]

40

Forskolin G (1α-hydroxy-6β,7β-diacetoxy-8,13-epoxy-labd-14-en-11-one; l-deacetyl-9-dehydroxyforskolin A; l-deacetyl-6-acetylforskolin E)

R, WP

China

[44], [45], [47], [49], [50]

41

Forskolin H (1α,6β-diacetoxy-8,13-epoxy-labd-14-en-11-one; 7-deacetoxy-9-dehydroxyforskolin A; plectromatin C)

R, WP

China

[44], [45], [47], [49]

42

Forskolin I (1α,6β-diacetoxy-7β,9α-dihydroxy-8,13-epoxy-labd-14-en-11-one; 7-deacetylforskolin A; 1-acetylforskolin C)

R, WP

China

[44], [45], [51], [52]

43

Forskolin J (1α,9α-dihydroxy-6β,7β-diacetoxy-8,13-epoxy-labd-14-en-11-one; 6-O-acetylforskolin;1-deacetylforskolin A; 7-acetylforskolin C)

R

China

[44], [51], [52]

44

1,6-Diacetoxy-9-deoxyforskolin (1α,6β, 7β-triacetoxy-8,13-epoxy-labd-14-en-11-one; forskolin K; 9-dehydoxyfoskolin A)

R, WP

China

[30], [44], [52]

45

6β-Hydroxy-8,13-epoxy-labd-14-en-11-one (forskolin L)

R, R

China, India

[35], [44], [52]
46

Coleosol (6β,9β-dihydroxy-8,13-epoxy-labd-14-en-11-one; 6β,9β-dihydroxy-11-oxomanoyloxide)

R

India

[43], [53]

47

1-Acetoxy coleosol (1α-acetoxy-6β,9α-dihydroxy-8,13-epoxy-labd-14-en-11-one)

R

India

[46]

48

Coleol (9α-hydroxy-8,13-epoxy-labd-14-en-11-one)

R

India

[35], [43], [54], [55]

49

11-Oxomanoyloxide (8,13-epoxy-labd-14-en-11-one)

R

India

[35]

50

Coleonol E (7α-acetoxy-6β-hydroxy-8,13-epoxy-labd-14-en-11-one)

R

India

[56]

51

Coleonol F (6β-acetoxy-7α,9α-dihydroxy-8,13-epoxy-labd-14-en-11-one)

R

India

[56]

52

Deoxycoleonol (7α-acetoxy-1α,6β-dihydroxy-8,13-epoxy-labd-14-en-11-one)

R

India

[57]

8,13-Epoxy-labd-diterpenoids with some deviations

53

3-Hydroxyforskolin

WP

China

[58]

54

3-Hydroxyisoforskolin

WP

China

[58]

55

13-Epi-9-deoxycoleonol (13-epi-9-deoxyforskolin; 7β-acetoxy-1α,6β-dihydroxy-8,13-epoxy-labd-14-en-11-one)

R

India

[59]

56

Coleonol C (6β-acetoxy-1α,7α,9α-trihydroxy-8,13-β-epoxy-labd-14-en-11-one)

R

India

[57]

57

Coleonone (8,13-epoxy-labd-14-en-12-one)

R

India

[54], [55]

58

Manoyl oxide (8,13-epoxy-labd-14-ene)

R

India

[28]

Miscellaneous labdane diterpenoids

59

13-Epi-sclareol

R

India

[60]

60

Forskoditerpene A (5β,9β,10α,12β‐9,12-cyclo-7,13E-labdadien-15-oic acid)

WP

China

[61]

61

12-Hydroxy-8,13E-labdadien-15-oic acid

WP

China

[39]

62

Coleolic acid (11-ol,13-Me,8(9),13(14)Z-labdadien-15-oic acid)

WP

China

[62]

63

Coleonic acid (11-one,13-Me,8(9),13(14)Z-labdadien-15-oic acid)

WP

China

[62]

8,13-Epoxy-labd-14-en-11-one-diterpene glycosides

64

Forskoditerpenoside A (6β-acetoxy-7β,9α-dihydroxy-8,13-epoxy-labd-14-en-11-one-1α-O-β-D-glucopyranoside)

WP

China

[63]

65

Forskoditerpenoside B (6β,7β-diacetoxy-9α-hydroxy-8,13-epoxy-labd-14-en-11-one-1α-O-β-D-glucopyranoside)

WP

China

[63]

66

Forskoditerpenoside C (6β-acetoxy-7β-hydroxy-8,13-epoxy-labd-14-en-11-one-1α -O-β-D-glucopyranoside)

WP

China

[61]

67

Forskoditerpenoside D (6β, 7β-diacetoxy- 8,13-epoxy-labd-14-en-11-one-1α -O-β-D-glucopyranoside)

WP

China

[61]

68

Forskoditerpenoside E (6β-acetoxy-8,13-epoxy-labd-14-en-11-one-1α-O-β-D-glucopyranoside)

WP

China

[61]

a L = leaf; R = root; S = stem; WP = whole plant

A series of labdane diterpenoids with the typical 8,13-epoxy-labd-14-en-11-one skeleton, differentiated in the substituent groups at C-1, C-6, C-7, and C-9 (structures 2652) ([Fig. 2]) were isolated mainly from the roots of P. barbatus grown in India as well as from the whole plant, roots, leaves of P. barbatus grown in China [4], [5], [10], [16], [30], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57] ([Table 1]). Forskolin (26) ([Fig. 2]) is the first main labdane diterpenoid isolated from the roots of the Indian P. barbatus. Some 8,13-epoxy-labdane diterpenoids with some deviations from the basic structure were identified, for example, those containing an additional hydroxy substituent at C-3 such as 3-hydroxyforskolin (53), and 3-hydroxyisoforskolin (54) [58], those with a β-axial orientation of the C-13/C-14 bond and α-equatorial orientation of the methyl group at C-16 such as 13-epi-9-deoxycoleonol (55) [59], and coleonol C (56) [57], or with the carbonyl function at C-12 or without carbonyl function such as coleonone (57) [54], [55], and manoyl oxide (58) [28] respectively ([Table 1], [Fig. 3]). Further labdane diterpenoids such as 13-epi-sclareol (59) [60], forskoditerpene A (60) [61], 12-hydroxy-8,13E-labdadien-15-oic acid (61) [39], coleolic acid (62) and coleonic acid (63) [62] were also isolated from different parts of P. barbatus ([Table 1], [Fig. 4]). Moreover, five minor 8,13-epoxy-labd-14-en-11-one diterpene glycosides such as forskoditerpenosides A (64), B (65), C (66), D (67), and E (68) were isolated from the whole plant of P. barbatus grown in China [61], [63] ([Table 1], [Fig. 5]).

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Essential oils

The chemical composition of the essential oils of P. barbatus varied according to location and date of harvest, and contained mainly mono- and sesquiterpenes. The main constituents of the essential oil distilled from the leaves of P. barbatus grown in Brazil were α-pinene, eremophyllene, myrcene, humulenone, β-caryophyllene, β-o-cymene, limonene, nerolidol and farnesol [64], [65]. In addition, the diterpene manool (1.0 %) was reported for the first time to be contained in the essential oil of the leaves [64]. In all, 91 components were detected in the essential oil obtained from the leaves of Rwandan P. barbatus. The main compounds were aromadendrene, borneol, α-fenchyl acetate, α-copaene, γ‐2-cadinene, caryophyllene oxide, T-cadinol, calamenene hydrate, and hydroxycalamenene [66], [67]. Steam distillation of the roots of P. barbatus grown in India and Brazil afforded an essential oil, the main constituents of which were found to be β-o-cymene, bornyl acetate, 3-decanone, α-santalene, α-pinene, β-pinene, β-caryophyllene, camphene, sabinene, β-ionone, (E,E)-farnesol, α‐cis-bergamotene and γ-curcumene [28], [64]. Furthermore, the presence of the diterpene abietatriene (0.7 %) (dehydroabietane) (19) ([Fig. 1]) was reported for the first time in the essential oil extracted from the roots of P. barbatus grown in Brazil [64]. Moreover, the essential oil of the stems of this plant afforded the major constituents, β-phellandrene, α-pinene, α-copaene, sabinene, caryophyllene oxide, limonene, β-caryophyllene, and α-humulene [64].

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Miscellaneous constituents

The monoterpene glycoside coleoside (cuminyl-O-β-D-glucopyranosyl-(1 → 2)-β-D-galactopyranoside) (69) [68], the sesquiterpenoids α-cedrol [16], [24] and 4β,7β,11-enantioeudesmantriol (70) [63], a number of pentacyclic triterpenoids of the ursane type such as α-amyrin [24], coleonolic acid (2-hydroxymethyl-A-(1)-nor-urs-19α-hydroxy-2(3),12(13)-dien-28-oic acid) (71) [69], euscaphic acid (2α,3α19α-trihydroxyurs-12-en-28-oic acid) (72) [58], myrianthic acid (2α,3α,19α,23-tetrahydroxyurs-12-en-28-oic acid) (73) [58], and uvaol (urs-12-ene-3β-28-diol) (74) [30], of the lupane type such as betulic acid [24], of the oleanane type such as arjunic acid (olean-12-en-28-oic acid,2α,3β,19α) (75) [58] and arjungenin [2,3,19,23-tetrahydroxy-olean-12-en-28-oic acid (2α,3β,4α,19α)] (76) [58] ([Fig. 6]) as well as the tetraterpenoid crocetin dialdehyde [70] and the sterols {ergosterol endoperoxide (5α,8α-epidioxy-ergosta-6,22-dien-3β‐ol) [30], 5α,8α-epidioxy-ergosta-6,9(11),22-trien-3β‐ol [30], stigmasterol [16], [71], and β-sitosterol [16], [24], [30]} were isolated from different tissues of P. barbatus distributed in India and China.

Only one flavonoid and one phenylpropanoid, namely genkwanin (7-O-methylapigenin) and guaiacol glycerin ether, respectively, [16] as well as the phenolic compounds caffeic acid [68], coleoside B (p-isopropylcatechol-4-O-β-D-glucopyranosyl(1 → 2)-β-D-galactopyranoside) (77) [72] and colexanthone (1-oxymethyl-3,5-dihydroxy-7-methyl-xanthone) (78) [62] ([Fig. 6]) were isolated from different parts of the Chinese and Indian P. barbatus. In addition three tetramethyl-substituted higher alkanes namely 2,6,10,14-tetramethylpentadecane, 2,6,10,14-tetramethylhexadecane, and 2,6,10,14-tetramethylhepatdecane were isolated from the roots of the Indian P. barbatus [28]. Moreover, five glycolipids, such as monogalactosyl diacylglycerol, digalactosyl diacylglycerol, trigalactosyl diacylglycerol, tetragalactosyl diacylglycerol, and sulfoquinovosyl diacylglycerol were detected in the leaves of P. barbatus grown in Brazil [73].

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Uses

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Ethnobotanical uses

P. barbatus has been used for centuries in Hindu and Ayurvedic traditional medicine as well as in the folk medicine of Brazil, tropical Africa and China for the treatment of various diseases [1], [3], [4], [6], [29], [45], [66], [74], [75], [76], [77], [78] ([Table 2]). In addition, P. barbatus is used to alleviate fever in East Africa and India, as a children's tonic and also as an emetic utilized by the Samburu of Kenya for strength [1]. In Uganda the plant is used to treat spiritual ailments [79]. In Africa, the plant is applied in ethnoveterinary medicine, for instance in Kenya, it is used to treat Coast Fever in cattle [1]. P. barbatus is used against snakebites in India, Gabon and Kenya, and as insecticide to protect grain stores [1], [66].

Table 2 Ethnobotanical uses of Plectranthus barbatus.

Digestive system

Respiratory system

Cardiovascular system

In India for abdominal colic [6]. For stomachache and as purgative in Kenya and for nausea in Southern Uganda [1], [74]. In Brazil, as a substitute for boldo (Peumus boldus) to treat gastric disturbances (e.g., gastritis and intestinal spasms) and hepatic disorders [1], [3], [29], [75]. Teeth and gum disorders [1].

Asthma, bronchitis, cold, cough and pneumonia [1], [4], [45], [66]. General respiratory ailments [1], [6], [74].

Angina, hemorrhage and hypertension [1], [6].

Nervous system

Pain, inflammation, musculoskeletal

Sensory

In Asia, for insomnia, convulsion [1], [6] and against dizziness and fluster [45]. In Tanzania for psychiatric problems [1].

Inflammation, abdominal and spasmodic pain, and painful micturition [1], [6]. Muscular, generalized pain, stiff neck, backache, bone dislocation, and rheumatism [1].

For conjunctivitis in Congo and earache in Kenya [1].

Skin

Metabolic & endocrine system

Infection

In East Africa (Kenya, Congo), for wounds and ringworms, to reduce swelling on bruises and as a bath for babies with measles [1], [74].

In Ayurvedic medicine for hypothyroidism [76]. As an emmenagogue, oral abortifacient [1], [77]. In Somalia as an aphrodisiac [1].

Throat and mouth infections, tonsillitis, gastrointestinal infections, genitorurinary infections (e.g., syphilis in Central Africa) and eye and ear infections [1]. In Rwanda, Kenya, French Guiana and Brazil to treat malaria [1], [66], [78]. In Kenya for measles [74].

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Non-medicinal uses

As reported by Lukhoba et al. [1], P. barbatus is planted as an ornamental and as a hedge, fence or boundary marker as well as soil improver for growing grains such as cowpeas, green grams and maize; it is also planted on the hillsides to prevent soil erosion and is used for making manure. The leaves of P. barbatus are cooked as a vegetable in Kenya and Yemen;it is fed to sheep, goats and cattle. In Kenya, the soft velvety leaves are used as sanitary tissue to clean milk guards and both the leaves and stems are used to hasten the ripening of bananas.

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References

  • 1 Lukhoba C W, Simmonds M S J, Paton A J. Plectranthus: a review of ethnobotanical uses.  J Ethnopharmacol. 2006;  103 1-24
  • 2 Hara H. On the Asiatic species of the genus Rabdosia (Labiatae).  J Jpn Bot. 1972;  47 193-203
  • 3 Schultz C, Bossolani M P, Torres L M B, Lima-Landman M T R, Lapa A J, Souccar C. Inhibition of the gastric H+,K+-ATPase by plectrinone A, a diterpenoid isolated from Plectranthus barbatus Andrews.  J Ethnopharmacol. 2007;  111 1-7
  • 4 Jin Q D, He B H. Minor constituents from Coleus forskohlii.  Acta Bot Yunn. 1998;  20 469-473
  • 5 de Souza N J, Dohadwalla A N, Reden J. Forskolin: a labdane diterpenoid with antihypertensive, positive inotropic, platelet aggregation inhibitory, and adenylate cyclase activating properties.  Med Res Rev. 1983;  3 201-219
  • 6 Dubey M P, Srimal R C, Nityanand S, Dhawan B N. Pharmacological studies on coleonol, a hypotensive diterpene from Coleus forskohlii.  J Ethnopharmacol. 1981;  3 1-13
  • 7 Zelnik R, Lavie D, Levy E C, Wang A H J, Paul I C. Barbatusin and cyclobutatusin, two novel diterpenoids from Coleus barbatus Bentham.  Tetrahedron. 1977;  33 1457-1467
  • 8 Dubey M P, Srimal R C, Patnaik G K, Dhawan B N. Hypotensive and spasmolytic activities of coleonol, active principle of Coleus forskohlii Briq.  Indian J Pharmacol. 1974;  6 15
  • 9 Tandon J S, Dhar M M, Ramakumar S, Venkatesan K. Structure of coleonol, a biologically active diterpene from Coleus forskohlii.  Indian J Chem Sect B Org Chem Incl Med Chem. 1977;  15 B 880-883
  • 10 Bhat S V, Bajwa B S, Dornauer H, de Souza N J, Fehlhaber H W. Structures and stereochemistry of new labdane diterpenoids from Coleus forskohlii Briq.  Tetrahedron Lett. 1977;  19 1669-1672
  • 11 Ramakumar S, Venkatesan K, Tandon J S, Dhar M M. Molecular and crystal structure of coleonol, C22H34O7.  Z Kristallogr. 1985;  173 81-86
  • 12 Viswanathan N, Gawad D H. Identity of forskolin with coleonol.  Indian J Chem Sect B Org Chem Incl Med Chem. 1985;  24 B 583
  • 13 Saksena A K, Green M J, Shue H J, Wong J K, McPhail A T. Identity of coleonol with forskolin: structure revision of a base-catalysed rearrangement product.  Tetrahedron Lett. 1985;  26 551-554
  • 14 Ammon H P, Müller A B. Forskolin: from an ayurvedic remedy to a modern agent.  Planta Med. 1985;  51 473-477
  • 15 Ruedi P. Novel diterpenoids from leaf glands of Plectranthus barbatus (Labiatae). The absolute configuration of the 2-hydroxypropyl group in coleon E.  Helv Chim Acta. 1986;  69 972-984
  • 16 Yao C S, Shen Y H, Xu Y L. The chemical constituents of Coleus forskohlii.  Nat Prod Res Dev. 2002;  14 1-6
  • 17 Yao C S, Xu Y L. The diterpenoid quinones from Coleus forskohlii.  Chin Chem Lett. 2001;  12 339-342
  • 18 Kubo I, Matsumoto T, Tori M, Asakawa Y. Structure of plectrin, an aphid antifeedant diterpene from Plectranthus barbatus.  Chem Lett. 1984;  9 1513-1516
  • 19 de Albuquerque R L, Kentopff M R, Machado M I L, Silva M G V, Matos F J de A, Morais S M, Braz-Filho R. Abietane diterpenoids isolated from Plectranthus barbatus Andrews.  Quim Nova. 2007;  30 1882-1886
  • 20 Wang A H J, Paul I C, Zelnik R, Mizuta K, Lavie D. Structure and absolute stereochemistry of the diterpenoid barbatusin.  J Am Chem Soc. 1973;  95 598-600
  • 21 Wang A H J, Paul I C, Zelnik R, Lavie D, Levy E C. Structure and stereochemistry of cyclobutatusin, a diterpenoid containing a four-membered ring.  J Am Chem Soc. 1974;  96 580-581
  • 22 Ruedi P, Eugster C H. Structure of coleon E, a new diterpenoid methylenequinone from Coleus barbatus species (Labiatae).  Helv Chim Acta. 1972;  55 1994-2014
  • 23 Ruedi P, Eugster C H. Structure of coleon F.  Helv Chim Acta. 1973;  56 1129-1132
  • 24 Xu L L, Lu J, Li W J, Kong L Y. Studies on the chemical constituents in root of Coleus forskohlii.  Zhongguo Zhong Yao Za Zhi. 2005;  30 1753-1755
  • 25 Liu Y, Wu H, Wang X M, Liu J, Xing X. Use of coleon C extracted from Coleus as inhibitor for tumor growth and tumor cell proliferation. Chinese Patent CN 1899273 A; 2007. 
  • 26 Kelecom A, Dos Santos T C, Medeiros W L B. Secoabietane diterpenes from Coleus barbatus.  Phytochemistry. 1987;  26 2337-2340
  • 27 Kelecom A, Dos Santos T C. Cariocal, a new seco-abietane diterpene from the labiate Coleus barbatus.  Tetrahedron Lett. 1985;  26 3659-3662
  • 28 Mathela D K, Kharkwal H B, Mathela C S. Terpenoids of roots of Coleus forskohlii.  Fitoterapia. 1986;  57 299-301
  • 29 Kelecom A. Isolation, structure determination, and absolute configuration of barbatusol, a new bioactive diterpene with a rearranged abietane skeleton from the labiate Coleus barbatus.  Tetrahedron. 1983;  39 3603-3608
  • 30 Li S, Yang Q R, Wang X M, Zou G A, Liu Y W. Chemical constituents of Coleus forskohlii replanted to Tongcheng.  Zhongcaoyao. 2006;  37 824-826
  • 31 Kelecom A, Dos Santos T C, Medeiros W L B. On the structure and absolute configuration of (−)-20-deoxocarnosol.  An Acad Bras Cienc. 1986;  58 53-59
  • 32 Kelecom A. An abietane diterpene from the labiate Coleus barbatus.  Phytochemistry. 1984;  23 1677-1679
  • 33 Kelecom A. 6-β-Hydroxycarnosol, a new minor diterpene from the false boldo Coleus barbatus Bentham (Labiatae).  Quim Nova. 1983;  6 117-118
  • 34 Shah V, Bhat S V, Bajwa B S, Dornauer H, de Souza N J. The occurrence of forskolin in the Labiatae.  Planta Med. 1980;  39 183-185
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  • 36 Liu C, Yao W, Meng K, Liu Y, Zhang S, Zeng S, Lu S, Li H. Isolation and purification of forskolin and identification of its chemical structure and biological activity.  Shengwu Huaxue Yu Shengwu Wuli Jinzhan. 1992;  19 74-76
  • 37 Zhang X H, Zhang W, Jin Q D, Xu Y L. Spectral characteristics of forskolins (1).  Nat Prod Res Dev. 2005;  17 163-165
  • 38 Bhat S V, Dohadwalla A N, Bajwa B S, Dadkar N K, Dornauer H, de Souza N J. The antihypertensive and positive inotropic diterpene forskolin: effects of structural modifications on its activity.  J Med Chem. 1983;  26 486-492
  • 39 Xu L L, Kong L Y. Labdane diterpenoids from Coleus forskohlii (Willd.) Briq.  J Integr Plant Biol. 2006;  48 478-481
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  • 41 Jin Q D, Xie X H, Mu Q Z. Study on the chemical constituents from Coleus forskohlii Briq.  Nat Prod Res Dev. 1990;  2 6-9
  • 42 Carpy A, Leger J M, Tandon J S, Saxena A K. Molecular and crystal structure of coleonol-B, C22H34O7.  Z Kristallogr. 1991;  194 229-233
  • 43 Prakash O, Roy R, Tandon J S, Dhar M M. Carbon-13 and proton two-dimensional NMR study of diterpenoids of Coleus forskohlii.  Magn Reson Chem. 1988;  26 117-119
  • 44 Xu L L, Kong L Y. Isolation and identification of labdane diterpenoids from the roots of Coleus forskohlii.  Chin J Nat Med. 2004;  2 344-347
  • 45 Yang Q R, Wu H Z, Wang X M, Zou G A, Liu Y W. Three new diterpenoids from Coleus forskohlii Briq.  J Asian Nat Prod Res. 2006;  8 355-360
  • 46 Roy R, Mishra A, Varma N, Tandon J S, Saux M, Carpy A. Minor diterpenes from Coleus forskohlii.  Phytochemistry. 1993;  34 1577-1580
  • 47 Xu Y L, Jin Q D, Liu J. Spectral characteristics of forskolins (3).  Nat Prod Res Dev. 2006;  18 (Suppl.) 79-81 97
  • 48 Khandelwal Y, Jotwani P K, Inamdar P K, de Souza N J, Rupp R H. Isolation, structure elucidation, and synthesis of 1-deoxyforskolin.  Tetrahedron. 1989;  45 763-766
  • 49 Shen Y H, Yao C S, Xu Y L. New diterpenoids from Coleus forskohlii.  Chin Chem Lett. 2002;  13 740-743
  • 50 Shan Y P, Wang X B, Kong L Y. Forskolin G.  Acta Crystallogr Sect E Struct Rep Online. 2006;  E62 o2408-o2410 http://journals.iucr.org/e/issues/2006/06/00/hk2036/index.html
  • 51 Shen Y H, Xu Y L. Two new diterpenoids from Coleus forskohlii.  J Asian Nat Prod Res. 2005;  7 811-815
  • 52 Yang W M, Jin Q D, Xu Y L. Spectral characteristics of forskolins (4).  Nat Prod Res Dev. 2007;  19 991-994
  • 53 Jauhari P K, Katti S B, Tandon J S, Dhar M M. Coleosol – a new diterpene from Coleus forskohlii.  Indian J Chem Sect B Org Chem Incl Med Chem. 1978;  16 B 1055-1057
  • 54 Singh S, Painuly P, Tandon J S. Diterpenes from Coleus forskohlii: stereochemistry of the carbonyl chromophore.  Indian J Chem Sect B Org Chem Incl Med Chem. 1984;  23 B 952-955
  • 55 Katti S B, Jauhari P K, Tandon J S. New diterpenes from Coleus forskohlii: structures of the diterpenes, coleonol-D, coleol and coleonone.  Indian J Chem Sect B Org Chem Incl Med Chem. 1979;  17 B 321-323
  • 56 Painuly P, Katti S B, Tandon J S. Diterpenes from Coleus forskohlii: structures of coleonol-E and coleonol-F.  Indian J Chem Sect B Org Chem Incl Med Chem. 1979;  18 B 214-216
  • 57 Tandon J S, Jauhari P K, Singh R S, Dhar M M. Structures of three new diterpenes, coleonol B, coleonol C and deoxycoleonol isolated from Coleus forskohlii.  Indian J Chem Sect B Org Chem Incl Med Chem. 1978;  16 B 341-345
  • 58 Shan Y P, Kong L Y. Isolation and identification of terpenes from Coleus forskohlii.  Chin J Nat Med. 2006;  4 271-274
  • 59 Tandon J S, Roy R, Balachandran S, Vishwakarma R A. Epi-deoxycoleonol, a new antihypertensive labdane diterpenoid from Coleus forskohlii.  Bioorg Med Chem Lett. 1992;  2 249-254
  • 60 Sashidhara K V, Rosaiah J N, Kumar A, Bid H K, Konwar R, Chattopadhyay N. Cell growth inhibitory action of an unusual labdane diterpene, 13-epi-sclareol in breast and uterine cancers in vitro.  Phytother Res. 2007;  21 1105-1108
  • 61 Shan Y, Xu L, Lu Y, Wang X, Zheng Q, Kong L, Niwa M. Diterpenes from Coleus forskohlii (WILLD.) BRIQ. (Labiatae).  Chem Pharm Bull. 2008;  56 52-56
  • 62 Liu Y, Wang X M, Wu H. Main components of Coleus forskohlii extract and relevant extraction method. Chinese Patent CN 1944384 A; 2007. 
  • 63 Shan Y, Wang X, Zhou X, Kong L, Niwa M. Two minor diterpene glycosides and an eudesman sesquiterpene from Coleus forskohlii.  Chem Pharm Bull. 2007;  55 376-381
  • 64 Kerntopf M R, de Albuquerque R L, Machado M I L, Matos F J A, Craveiro A A. Essential oils from leaves, stems and roots of Plectranthus barbatus Andr. (Labiatae) grown in Brazil.  J Essent Oil Res. 2002;  14 101-102
  • 65 Mancini B, Rubino C L, Pozetti G L, Mancini M A D. Chromatographic study of essential oils from plants of Araraquara region. 1. Thin-layer and vapor-phase chromatographic analysis of essential oil from leaves of Coleus barbatus Labiatae.  Rev Fac Farm Odontol Araraquara. 1972;  6 41-46
  • 66 Muhayimana A, Chalchat J C, Garry R P. Chemical composition of essential oils of some medicinal plants from Rwanda.  J Essent Oil Res. 1998;  10 251-259
  • 67 Chalchat J C, Garry R P, Muhayimana A. Aromatic plants of Rwanda. Chemical composition of two Labiaceae, Plectranthus barbatus and Plectranthus sylvestris.  Riv Ital EPPOS. 1996;  7 665-674
  • 68 Ahmed B, Vishwakarma R A. Coleoside, a monoterpene glycoside from Coleus forskohlii.  Phytochemistry. 1988;  27 3309-3310
  • 69 Roy R, Vishwakarma R A, Varma N, Tandon J S. Coleonolic acid, a rearranged ursane triterpenoid from Coleus forskohlii.  Tetrahedron Lett. 1990;  31 3467-3470
  • 70 Tandon J S, Katti S B, Rueedi P, Eugster C H. Crocetin dialdehyde from Coleus forskohlii Briq., Labiatae.  Helv Chim Acta. 1979;  62 2706-2707
  • 71 Shah V C, D'Sa A S, de Souza N J. Chonemorphine, stigmasterol, and ecdysterone: steroids isolated through bioassay-directed plant screening programs.  Steroids. 1989;  53 559-565
  • 72 Ahmed B, Merotra R. Coleoside-B: a new phenolic glycoside from Coleus forskohlii.  Pharmazie. 1991;  46 157-158
  • 73 Mendes B G, Machado M J, Falkenberg M. Screening of glycolipids in medicinal plants.  Rev Bras Farmacognosia. 2006;  16 568-575
  • 74 Matu E N, van Staden J. Antibacterial and anti-inflammatory activities of some plants used for medicinal purposes in Kenya.  J Ethnopharmacol. 2003;  87 35-41
  • 75 Camara C C, Nascimento N R, Macedo-Filho C L, Almeida F B, Fonteles M C. Antispasmodic effect of the essential oil of Plectranthus barbatus and some major constituents on the guinea-pig ileum.  Planta Med. 2003;  69 1080-1085
  • 76 Ding X, Staudinger J L. Induction of drug metabolism by forskolin: the role of the pregnane X receptor and the protein kinase A signal transduction pathway.  J Pharmacol Exp Ther. 2005;  312 849-856
  • 77 Almeida F C, Lemonica I P. The toxic effects of Coleus barbatus B. on the different periods of pregnancy in rats.  J Ethnopharmacol. 2000;  73 53-60
  • 78 Vigneron M, Deparis X, Deharo E, Bourdy G. Antimalarial remedies in French Guiana: a knowledge attitudes and practices study.  J Ethnopharmacol. 2005;  98 351-360
  • 79 Tabuti J R, Lye K A, Dhillion S S. Traditional herbal drugs of Bulamogi, Uganda: plants, use and administration.  J Ethnopharmacol. 2003;  88 19-44

Prof. Dr. Matthias F. Melzig

Institute of Pharmacy
Free University Berlin

Königin-Luise-Str. 2 + 4

14195 Berlin

Germany

Phone: + 49 30 83 85 14 51

Fax: + 49 30 83 85 14 61

Email: melzig@zedat.fu-berlin.de

#

References

  • 1 Lukhoba C W, Simmonds M S J, Paton A J. Plectranthus: a review of ethnobotanical uses.  J Ethnopharmacol. 2006;  103 1-24
  • 2 Hara H. On the Asiatic species of the genus Rabdosia (Labiatae).  J Jpn Bot. 1972;  47 193-203
  • 3 Schultz C, Bossolani M P, Torres L M B, Lima-Landman M T R, Lapa A J, Souccar C. Inhibition of the gastric H+,K+-ATPase by plectrinone A, a diterpenoid isolated from Plectranthus barbatus Andrews.  J Ethnopharmacol. 2007;  111 1-7
  • 4 Jin Q D, He B H. Minor constituents from Coleus forskohlii.  Acta Bot Yunn. 1998;  20 469-473
  • 5 de Souza N J, Dohadwalla A N, Reden J. Forskolin: a labdane diterpenoid with antihypertensive, positive inotropic, platelet aggregation inhibitory, and adenylate cyclase activating properties.  Med Res Rev. 1983;  3 201-219
  • 6 Dubey M P, Srimal R C, Nityanand S, Dhawan B N. Pharmacological studies on coleonol, a hypotensive diterpene from Coleus forskohlii.  J Ethnopharmacol. 1981;  3 1-13
  • 7 Zelnik R, Lavie D, Levy E C, Wang A H J, Paul I C. Barbatusin and cyclobutatusin, two novel diterpenoids from Coleus barbatus Bentham.  Tetrahedron. 1977;  33 1457-1467
  • 8 Dubey M P, Srimal R C, Patnaik G K, Dhawan B N. Hypotensive and spasmolytic activities of coleonol, active principle of Coleus forskohlii Briq.  Indian J Pharmacol. 1974;  6 15
  • 9 Tandon J S, Dhar M M, Ramakumar S, Venkatesan K. Structure of coleonol, a biologically active diterpene from Coleus forskohlii.  Indian J Chem Sect B Org Chem Incl Med Chem. 1977;  15 B 880-883
  • 10 Bhat S V, Bajwa B S, Dornauer H, de Souza N J, Fehlhaber H W. Structures and stereochemistry of new labdane diterpenoids from Coleus forskohlii Briq.  Tetrahedron Lett. 1977;  19 1669-1672
  • 11 Ramakumar S, Venkatesan K, Tandon J S, Dhar M M. Molecular and crystal structure of coleonol, C22H34O7.  Z Kristallogr. 1985;  173 81-86
  • 12 Viswanathan N, Gawad D H. Identity of forskolin with coleonol.  Indian J Chem Sect B Org Chem Incl Med Chem. 1985;  24 B 583
  • 13 Saksena A K, Green M J, Shue H J, Wong J K, McPhail A T. Identity of coleonol with forskolin: structure revision of a base-catalysed rearrangement product.  Tetrahedron Lett. 1985;  26 551-554
  • 14 Ammon H P, Müller A B. Forskolin: from an ayurvedic remedy to a modern agent.  Planta Med. 1985;  51 473-477
  • 15 Ruedi P. Novel diterpenoids from leaf glands of Plectranthus barbatus (Labiatae). The absolute configuration of the 2-hydroxypropyl group in coleon E.  Helv Chim Acta. 1986;  69 972-984
  • 16 Yao C S, Shen Y H, Xu Y L. The chemical constituents of Coleus forskohlii.  Nat Prod Res Dev. 2002;  14 1-6
  • 17 Yao C S, Xu Y L. The diterpenoid quinones from Coleus forskohlii.  Chin Chem Lett. 2001;  12 339-342
  • 18 Kubo I, Matsumoto T, Tori M, Asakawa Y. Structure of plectrin, an aphid antifeedant diterpene from Plectranthus barbatus.  Chem Lett. 1984;  9 1513-1516
  • 19 de Albuquerque R L, Kentopff M R, Machado M I L, Silva M G V, Matos F J de A, Morais S M, Braz-Filho R. Abietane diterpenoids isolated from Plectranthus barbatus Andrews.  Quim Nova. 2007;  30 1882-1886
  • 20 Wang A H J, Paul I C, Zelnik R, Mizuta K, Lavie D. Structure and absolute stereochemistry of the diterpenoid barbatusin.  J Am Chem Soc. 1973;  95 598-600
  • 21 Wang A H J, Paul I C, Zelnik R, Lavie D, Levy E C. Structure and stereochemistry of cyclobutatusin, a diterpenoid containing a four-membered ring.  J Am Chem Soc. 1974;  96 580-581
  • 22 Ruedi P, Eugster C H. Structure of coleon E, a new diterpenoid methylenequinone from Coleus barbatus species (Labiatae).  Helv Chim Acta. 1972;  55 1994-2014
  • 23 Ruedi P, Eugster C H. Structure of coleon F.  Helv Chim Acta. 1973;  56 1129-1132
  • 24 Xu L L, Lu J, Li W J, Kong L Y. Studies on the chemical constituents in root of Coleus forskohlii.  Zhongguo Zhong Yao Za Zhi. 2005;  30 1753-1755
  • 25 Liu Y, Wu H, Wang X M, Liu J, Xing X. Use of coleon C extracted from Coleus as inhibitor for tumor growth and tumor cell proliferation. Chinese Patent CN 1899273 A; 2007. 
  • 26 Kelecom A, Dos Santos T C, Medeiros W L B. Secoabietane diterpenes from Coleus barbatus.  Phytochemistry. 1987;  26 2337-2340
  • 27 Kelecom A, Dos Santos T C. Cariocal, a new seco-abietane diterpene from the labiate Coleus barbatus.  Tetrahedron Lett. 1985;  26 3659-3662
  • 28 Mathela D K, Kharkwal H B, Mathela C S. Terpenoids of roots of Coleus forskohlii.  Fitoterapia. 1986;  57 299-301
  • 29 Kelecom A. Isolation, structure determination, and absolute configuration of barbatusol, a new bioactive diterpene with a rearranged abietane skeleton from the labiate Coleus barbatus.  Tetrahedron. 1983;  39 3603-3608
  • 30 Li S, Yang Q R, Wang X M, Zou G A, Liu Y W. Chemical constituents of Coleus forskohlii replanted to Tongcheng.  Zhongcaoyao. 2006;  37 824-826
  • 31 Kelecom A, Dos Santos T C, Medeiros W L B. On the structure and absolute configuration of (−)-20-deoxocarnosol.  An Acad Bras Cienc. 1986;  58 53-59
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Prof. Dr. Matthias F. Melzig

Institute of Pharmacy
Free University Berlin

Königin-Luise-Str. 2 + 4

14195 Berlin

Germany

Phone: + 49 30 83 85 14 51

Fax: + 49 30 83 85 14 61

Email: melzig@zedat.fu-berlin.de

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Fig. 1 Abietane diterpenoids.

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Fig. 2 8,13-Epoxylabd-14-en-11-one diterpenoids.

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Fig. 3 8,13-Epoxylabdane diterpenoids with some changes from the basic structure.

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Fig. 4 Miscellaneous labdane diterpenoids.

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Fig. 5 8,13-Epoxylabd-14-en-11-one diterpene glycosides.

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Fig. 6 Miscellaneous constituents.

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Fig. 7 6-(3-Dimethylaminopropionyl)-forskolin hydrochloride (NKH477).